Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewDMP 543
Description: Potent, orally active ACh release enhancer
Chemical Name: 10,10-bis[(2-Fluoro-4-pyridinyl)methyl]-9(10H)-anthracenone
Purity: ≥99% (HPLC)
Biological Activity for DMP 543
DMP 543 is an acetylcholine release stimulator. Potently enhances K+-stimulated [3H]-ACh release from rat hippocampal slices (EC50 = 700 nM), and increases release of dopamine and glutamate (EC50 values are 0.25 and 0.22 μM, respectively). Orally active in vivo; increases ACh levels in rats (with a minimum effective dose of 1 mg/kg) and exerts a long duration of action. More potent than linopirdine (Cat. No. 1999) both in vitro and in vivo. Also K+ channel blocker.
Technical Data for DMP 543
| M. Wt | 412.44 |
| Formula | C26H18F2N2O |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 160588-45-4 |
| PubChem ID | 9887884 |
| InChI Key | MUJBUUDUXGDXLW-UHFFFAOYSA-N |
| Smiles | FC1=CC(CC2(CC3=CC(F)=NC=C3)C3=CC=CC=C3C(=O)C3=C2C=CC=C3)=CC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DMP 543
References for DMP 543
References are publications that support the biological activity of the product.
Zaczek et al (1998) Two new potent neurotransmitter release enhancers, 10,10-Bis(4-pyridinylmethyl)-9(10H)-anthracenone and 10,10-Bis(2-fluoro-4-pyridinylmethyl)-9(10H)-anthracenone: comparison to linopirdine. J.Pharmacol.Exp.Ther. 285 724 PMID: 9580619
Earl et al (1998) 2-Fluoro-4-pyridinylmethyl analogues of linopirdine as orally active acetylcholine release-enhancing agents with good efficacy and duration of action. J.Med.Chem. 41 4615 PMID: 9804701
View Related Products by Target
Keywords: DMP 543, DMP 543 supplier, K+, channels, blockers, potent, ACh, release, enhancer, Potent, orally, active, Potassium, Channels, Non-Selective, Acetylcholine, Nicotinic, Receptors, nAChR, Muscarinic, DMP543, Other, Non-selective, Muscarinics, Voltage-Gated, 2330, Tocris Bioscience
1 Citation for DMP 543
Citations are publications that use Tocris products. Selected citations for DMP 543 include:
Ipavec et al (2011) KV7 channels regulate muscle tone and nonadrenergic noncholinergic relaxation of the rat gastric fundus. Pharmacol Res 64 397 PMID: 21740972
Reviews for DMP 543
There are currently no reviews for this product. Be the first to review DMP 543 and earn rewards!
Have you used DMP 543?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Nicotinic ACh Receptors Scientific Review
Updated in 2014, this review by Sue Wonnacott summarizes the diverse structure and function of nicotinic acetylcholine receptors and gives an in-depth review of the ligands available for nAChR research. Compounds available from Tocris are listed.