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Description: Potent and selective kainate agonist
Chemical Name: (2S,3S,4R,5'R)-2-Carboxy-4-(5'-carboxy-1'-methyl-1Z,3E-hexadienyl)-3-pyrrolidineacetic acid
Purity: ≥95% (HPLC)
Biological Activity for Domoic acid
Domoic acid is a kainate receptor agonist. More potent and possibly more selective than kainate at kainate receptors, as demonstrated in electrophysiological studies.
Technical Data for Domoic acid
| M. Wt | 311.33 |
| Formula | C15H21NO6 |
| Storage | Desiccate at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 14277-97-5 |
| PubChem ID | 5282253 |
| InChI Key | VZFRNCSOCOPNDB-AOKDLOFSSA-N |
| Smiles | [H][C@](C)([C@](O)=O)/C=C/C=[C@@](C)\[C@H]1CN[C@H]([C@@](O)=O)[C@H]1CC(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Domoic acid
References for Domoic acid
References are publications that support the biological activity of the product.
Agrawal and Evans (1986) The primary afferent depolarizing action of kainate in the rat. Br.J.Pharmacol. 87 345 PMID: 3513882
Debonnel et al (1989) Domoic acid, the alleged 'mussel toxin', might produce its neurotoxic effect through kainate receptor activation: an electro-physiological study in rat dorsal hippocampus. Can.J.Physiol.Pharmacol. 67 29 PMID: 2540893
Watkins et al (1990) Experiments with kainate and quisqualate agonists and antagonists in relation to the sub-classification of 'non-NMDA' receptors. Excitatory Amino Acids and Synaptic Plasticity. Ed 49
Hampson and Manalo (1998) The activation of glutamate receptors by kainic acid and domoic acid. Nat.Toxins 6 153 PMID: 10223631
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Keywords: Domoic acid, Domoic acid supplier, Potent, selective, kainate, agonists, Glutamate, Kainate, Receptors, iGluR, Ionotropic, 0269, Tocris Bioscience
1 Citation for Domoic acid
Citations are publications that use Tocris products. Selected citations for Domoic acid include:
Rojas et al (2013) Activation of group I metabotropic glutamate receptors potentiates heteromeric kainate receptors. Mol Pharmacol 83 106 PMID: 23066089
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