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Submit ReviewDPNI-caged-GABA
Description: Nitroindoline-caged GABA
Chemical Name: 1-(4-Aminobutanoyl)-4-[1,3-bis(dihydroxyphosphoryloxy)propan-2-yloxy]-7-nitroindoline
Purity: ≥98% (HPLC)
Biological Activity for DPNI-caged-GABA
Nitroindoline-caged GABA (Cat.No. 0344) with similar photochemical properties to MNI-glutamate (Cat. No. 1490); for example, the same quantum yield (0.085). Highly water soluble; exhibits fast photorelease that is efficient at near-UV and 405 nm wavelengths.
Licensing Information
Sold under licence from the Medical Research Council.
Technical Data for DPNI-caged-GABA
| M. Wt | 499.3 |
| Formula | C15H23N3O12P2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 927866-58-8 |
| PubChem ID | 15953814 |
| InChI Key | QLCHBTSDKGMLRN-UHFFFAOYSA-N |
| Smiles | O=C(CCCN)N2C1=C([N+]([O-])=O)C=CC(OC(COP(O)(O)=O)COP(O)(O)=O)=C1CC2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DPNI-caged-GABA
References for DPNI-caged-GABA
References are publications that support the biological activity of the product.
Wieboldt et al (1994) Synthesis and photochemistry of photolabile derivatives of gamma-aminobutyric acid for chemical kinetic investigations of the gamma-aminobutyric acid receptor in the millisecond time region. Biochemistry 33 1526 PMID: 8312272
Trigo et al (2009) Laser photolysis of DPNI-GABA, a tool for investigating the properties and distribution of GABA receptors and for silencing neurons in situ. J.Neurosci.Meths. 181 159 PMID: 19422852
Trigo (2010) Presynaptic miniature GABAergic currents in developing interneurons. Neuron 66 235 PMID: 20435000
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2 Citations for DPNI-caged-GABA
Citations are publications that use Tocris products. Selected citations for DPNI-caged-GABA include:
Nunez-Parra et al (2013) Disruption of centrifugal inhibition to olfactory bulb granule cells impairs olfactory discrimination. PLoS One 110 14777 PMID: 23959889
Spoljaric et al (2019) KCC2-Mediated Cl- Extrusion Modulates Spontaneous Hippocampal Network Events in Perinatal Rats and Mice. Cell Rep 26 1073 PMID: 30699338
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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