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Submit ReviewDPPE fumarate
Description: Inhibitor of histamine binding at the intracellular binding site
Chemical Name: N,N-Diethyl-2-[4-(phenylmethyl)phenoxy]ethanamine fumarate
Biological Activity for DPPE fumarate
Binds with high affinity to the antiestrogen binding site but not to the estrogen receptor. Induces of sterol accumulation in MCF7 cells. An inhibitor of histamine binding at the intracellular histamine (Hlc) site.
Technical Data for DPPE fumarate
| M. Wt | 399.49 |
| Formula | C19H25NO.C4H4O4 |
| Storage | Desiccate at -20°C |
| CAS Number | 1185241-83-1 |
| PubChem ID | 45073473 |
| InChI Key | ZOOMDYHTGZSGDD-WLHGVMLRSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].CCN(CC)CCOC1=CC=C(CC2=CC=CC=C2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DPPE fumarate
Certificate of Analysis is currently unavailable on-line.
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References for DPPE fumarate
References are publications that support the biological activity of the product.
Brandes et al (1990) Histamine as an intracellular messenger. Biochem.Pharmacol. 40 1677 PMID: 2242003
Brandes and Hermonat (1984) A diphenylmethane derivative specific for the antiestrogen binding site found in rat liver microsomes. Biochem.Biophys.Res.Commun. 123 724 PMID: 6548377
Sturman et al (1994) Modulation of the intracellular and H3-histamine receptors and chemically-induced seizures in mice. Agents Actions 41 C68 PMID: 7976808
Kedjouar et al (2004) Molecular characterization of the microsomal tamox. binding site. J.Biol.Chem. 279 34048 PMID: 15175332
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Keywords: DPPE fumarate, DPPE fumarate supplier, Ligand, antiestrogen, binding, site, inhibitors, inhibits, histamine, intracellular, ER, ERR, Estrogen, Receptors, Histaminergic-, Compounds, Histaminergic-Related, and, Related, 0743, Tocris Bioscience
1 Citation for DPPE fumarate
Citations are publications that use Tocris products. Selected citations for DPPE fumarate include:
Dolma et al (2016) Inhibition of Dopamine Receptor D4 Impedes Autophagic Flux, Proliferation, and Survival of Glioblastoma Stem Cells. Cancer Cell 29 859 PMID: 27300435
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.