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Submit ReviewDQP 1105
Description: GluN2C/GluN2D-selective NMDA antagonist
Chemical Name: 5-(4-Bromophenyl)-3-(1,2-dihydro-6-methyl-2-oxo-4-phenyl-3-quinolinyl)-4,5-dihydro-γ-oxo-1H-pyrazole-1-butanoic acid
Purity: ≥97% (HPLC)
Biological Activity for DQP 1105
DQP 1105 is a noncompetitive NMDA receptor antagonist; displays over 50-fold selectivity for GluN2D- and GluN2C-containing receptors over GluN2B-, GluK2-, GluA1- and GluN2A-containing receptors (IC50 values are 2.7, 8.5, 121, 153, 198 and 206 μM, respectively). Reduces frequency of channel opening.
Please refer to IUPHAR Guide to Pharmacology for the most recent naming conventions.
Compound Libraries for DQP 1105
DQP 1105 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for DQP 1105
| M. Wt | 558.42 |
| Formula | C29H24BrN3O4 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 380560-89-4 |
| PubChem ID | 2723792 |
| InChI Key | JIQFFACVQXXHMY-YDALLXLXSA-N |
| Smiles | O=C2C(C4=NN(C(CCC(O)=O)=O)C(C5=CC=C(Br)C=C5)C4)=C(C3=CC=CC=C3)C1=CC(C)=CC=C1N2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for DQP 1105
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 55.84 | 100 |
Preparing Stock Solutions for DQP 1105
The following data is based on the product molecular weight 558.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.79 mL | 8.95 mL | 17.91 mL |
| 5 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 10 mM | 0.18 mL | 0.9 mL | 1.79 mL |
| 50 mM | 0.04 mL | 0.18 mL | 0.36 mL |
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Product Datasheets for DQP 1105
References for DQP 1105
References are publications that support the biological activity of the product.
Acker et al (2011) Mechanism for noncompetitive inhibition by novel GluN2C/D N-MthD.-aspartate receptor subunit-selective modulators. Mol.Pharmacol. 80 782 PMID: 21807990
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Keywords: DQP 1105, DQP 1105 supplier, DQP1105, supplier, NMDAD, Glu2NC, antagonists, selective, noncompetitive, inhibitors, inhibits, NMDA, Receptors, 4491, Tocris Bioscience
2 Citations for DQP 1105
Citations are publications that use Tocris products. Selected citations for DQP 1105 include:
Brancaccio et al (2017) Astrocytes Control Circadian Timekeeping in the Suprachiasmatic Nucleus via Glutamatergic Signaling. Neuron 93 1420 PMID: 28285822
Lozovaya et al (2014) Selective suppression of excessive GluN2C expression rescues early epilepsy in a tuberous sclerosis murine model. Nat Commun 5 4563 PMID: 25081057
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