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Submit ReviewDV 7028 hydrochloride
Description: Selective 5-HT2A antagonist; antithrombotic
Chemical Name: 3-[2-[4-(4-Fluorobenzoyl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-2H-pyrido[1,2-a]-1,3,5-triazine-2,4(3H)-dione hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for DV 7028 hydrochloride
DV 7028 hydrochloride is a selective 5-HT2A receptor antagonist (Ki = 22 nM for at 5-HT2 receptors). Exhibits no affinity for 5-HT1A, 5-HT1B or 5-HT1D receptors. Inhibits collagen-induced serotonin secretion and platelet aggregation; displays no effect on serotonin uptake by platelets. Shown to inhibit arterial thrombus formation, but not venous thrombosis, in rat models.
Technical Data for DV 7028 hydrochloride
| M. Wt | 436.91 |
| Formula | C21H25FN4O3.HCl |
| Storage | Desiccate at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 133364-62-2 |
| PubChem ID | 19746041 |
| InChI Key | MEULLZRAYZSDGF-UHFFFAOYSA-N |
| Smiles | O=C(C4=CC=C(F)C=C4)C(CC3)CCN3CCN2C(N1CCCCC1=NC2=O)=O.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for DV 7028 hydrochloride
References for DV 7028 hydrochloride
References are publications that support the biological activity of the product.
Pawlak et al (1998) A potent 5-hydroxytryptamine receptor (5-HT2A) antagonist, DV-7028, delays arterial thrombosis development in rats. Thromb.Res. 90 259 PMID: 9700856
Shibano et al (1992) Pharmacological profile of a new 5-hydroxytryptamine 2 receptor antagonist, DV-7028. Arch.Int.Pharmacodyn.Ther. 319 114 PMID: 1285670
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.