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Discontinued Product
1009 has been discontinued.
View all Glutamate (Metabotropic) Group I Receptors products.
Description: Group I and II mGlu antagonist
Chemical Name: (RS)-α-Ethyl-4-carboxyphenylglycine
Purity: ≥99% (HPLC)
Biological Activity for E4CPG
Novel group I/group II metabotropic glutamate receptor antagonist, more potent than (RS)-MCPG (Cat. No. 0336).
Technical Data for E4CPG
| M. Wt | 223.23 |
| Formula | C11H13NO4 |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 170846-89-6 |
| PubChem ID | 3937355 |
| InChI Key | AIEFWRHRHFRLFT-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)(CC)C1=CC=C(C(O)=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for E4CPG
References for E4CPG
References are publications that support the biological activity of the product.
Bedingfield et al (1995) Structure-activity relationships for a series of phenylglycine derivatives acting at metabotropic glutamate receptors (mGluRs). Br.J.Pharmacol. 116 3323 PMID: 8719814
Sekiyama et al (1996) Structure-activity relationships of new agonists and antagonists of different metabotropic glutamate receptor subtypes. Br.J.Pharmacol. 117 1493 PMID: 8730745
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Keywords: E4CPG, E4CPG supplier, Group, II, group, I, mGlur, antagonists, Receptors, mGlu2, mGlu3, mGluR2, mGluR3, Glutamate, Metabotropic, mGlu1, mGlu5, mGluR1, mGluR5, (Metabotropic), 1009, Tocris Bioscience
2 Citations for E4CPG
Citations are publications that use Tocris products. Selected citations for E4CPG include:
Balakrishnan et al (2009) Slow glycinergic transmission mediated by transmitter pooling. Nat Neurosci 12 286 PMID: 19198604
Newman (2005) Calcium increases in retinal glial cells evoked by light-induced neuronal activity. Neuropharmacology 25 5502 PMID: 15944378
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Metabotropic Glutamate Receptors Scientific Review
Written by Francine Acher, this review discusses the pharmacology and therapeutic potential of mGlu receptors, and the compounds acting upon them; compounds available from Tocris are listed.
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The key feature of drug addiction is the inability to stop using a drug despite clear evidence of harm. This poster describes the brain circuits associated with addiction, and provides an overview of the main classes of addictive drugs and the neurotransmitter systems that they target.
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Huntington's Disease Poster
Huntington's disease (HD) is a severe monogenic neurodegenerative disorder, which is characterized by the prevalent loss of GABAergic medium spiny neurons (MSN) in the striatum. This poster summarizes the effects of mutant huntingtin aggregation implicated in the pathology of HD, as well as highlighting the use of iPSCs for HD modeling.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.