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Ebio1

Cat. No. 8137 Submit a Review Datasheet / COA / SDS
Pricing Availability   Qty
Description: KCNQ2 activator
Chemical Name: N-(1,2-Dihydro-5-acenaphthylenyl)-4-fluorobenzamide
Purity: ≥98% (HPLC)
Datasheet
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Ebio1

Ebio1 is an activator of KCNQ2 voltage-gated potassium channels (EC50 = 247 nM). Ebio1 activates KCNQ2 by increasing both the open probability and the conductance of the channel. Ebio1 has no effect on the voltage sensitivity of KCNQ1, KCNQ3, KCNQ4 and KCNQ5.

Technical Data for Ebio1

M. Wt 291.33
Formula C19H14FNO
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 339287-36-4
PubChem ID 759702
InChI Key VROYHHCUXRMIQY-UHFFFAOYSA-N
Smiles O=C(C1=CC=C(C=C1)F)NC2=CC=C3C4=C(CC3)C=CC=C42

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Ebio1

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 29.13 100
ethanol 5.83 20

Preparing Stock Solutions for Ebio1

The following data is based on the product molecular weight 291.33. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.43 mL 17.16 mL 34.33 mL
5 mM 0.69 mL 3.43 mL 6.87 mL
10 mM 0.34 mL 1.72 mL 3.43 mL
50 mM 0.07 mL 0.34 mL 0.69 mL

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References for Ebio1

References are publications that support the biological activity of the product.

Zhang et al (2024) A small-molecule activation mechanism that directly opens the KCNQ2 channel. Nat.Chem.Biol. 20 847 PMID: 38167918

If you know of a relevant reference for Ebio1, please let us know.

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Keywords: Ebio1, Ebio1 supplier, KCNQ, channel, Potassium, KV, 7.2, Channels, voltage-gated, Voltage-Gated, 8137, Tocris Bioscience

Citations for Ebio1

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