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Description: Glutathione peroxidase mimic; peroxynitrite scavenger
Chemical Name: 2-Phenyl-1,2-benzisoselenazol-3(2H)-one
Purity: ≥98% (HPLC)
Biological Activity for Ebselen
Ebselen is a glutathione peroxidase mimic; peroxynitrite scavenger. Inhibits ferroptosis. Also inhibits lipoxygenase, cyclooxygenase, nitric oxide synthase, protein kinase C and H+/K+-ATPase activity. Inhibits the hepatic carcinogenic effects of aflatoxin B1. Antioxidant and anti-inflammatory. Selectively inhibits Gq protein signaling and enhances differentiation of brown adipocytes. Inhibits SARS-CoV-2 Mpro in vitro (IC50 = 0.67 μM in FRET assay)
Technical Data for Ebselen
| M. Wt | 274.18 |
| Formula | C13H9NOSe |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 60940-34-3 |
| PubChem ID | 3194 |
| InChI Key | DYEFUKCXAQOFHX-UHFFFAOYSA-N |
| Smiles | O=C2C1=CC=CC=C1[Se]N2C3=CC=CC=C3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ebselen
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.42 | 100 |
Preparing Stock Solutions for Ebselen
The following data is based on the product molecular weight 274.18. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.65 mL | 18.24 mL | 36.47 mL |
| 5 mM | 0.73 mL | 3.65 mL | 7.29 mL |
| 10 mM | 0.36 mL | 1.82 mL | 3.65 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.73 mL |
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Product Datasheets for Ebselen
References for Ebselen
References are publications that support the biological activity of the product.
Schewe (1995) Molecular actions of ebselen--an antiinflammatory antioxidant. Gen.Pharmacol. 26 1153 PMID: 7590103
Yang et al (2000) Inhibition of ebselen on aflatoxin B(1)-induced hepatocarcinogenesis in Fischer 344 rats. Carcinogenesis 21 2237 PMID: 11133813
Fujisawa and Kadoma (2005) Kinetic studies of the radical-scavenging activity of ebselen, a seleno-organic compound. Anticancer Res. 25 3989 PMID: 16309189
Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095
Xie et al (2016) Ferroptosis: process and function. Cell Death Differ. 23 369 PMID: 26794443
Jin et al (2020) Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors. Nature. 582 289 PMID: 32272481
If you know of a relevant reference for Ebselen, please let us know.
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Keywords: Ebselen, Ebselen supplier, Glutathione, peroxidase, mimic, peroxynitrite, scavenger, inhibts, inhibitors, inhibits, lipoxygenases, cyclooxygenases, nitric, oxide, synthases, protein, kinase, C, H+, K+, atpases, Antioxidant, anti-inflammatory, ferroptosis, Gq, proteins, signaling, adipoc, Antioxidants, Ferroptosis, Heterotrimeric, G-protein, GTPases, COVID-19, 3C, and, 3CL, Proteases, Coronavirus, 5245, Tocris Bioscience
2 Citations for Ebselen
Citations are publications that use Tocris products. Selected citations for Ebselen include:
Ginam et al (2021) β2-adrenergic receptor regulates ER-mitochondria contacts. Sci Rep 11 21477 PMID: 34728663
Kuschak et al (2019) Cell-permeable high-affinity tracers for Gq proteins provide structural insights, reveal distinct binding kinetics, and identify small molecule inhibitors. Br.J.Pharmacol. 177 1898 PMID: 31881095
Do you know of a great paper that uses Ebselen from Tocris? Please let us know.
Reviews for Ebselen
Average Rating: 3 (Based on 1 Review.)
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Used as a Nucleoside Diphosphate Kinase inhibitor.
By
Anonymous on 09/30/2024
Assay Type: Ex Vivo
Species: Rat
Cell Line/Tissue: Primary hippocampal neurons
The drug was incubated acutely at 100 μM as a potential NDK inhibitor.