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Submit ReviewEdelfosine
Discontinued Product
This product has been withdrawn from sale and is superseded by ET 18-OCH<sub>3</sub> (Cat. No. 7462)
Description: Selective PI-PLC inhibitor, also PAF receptor agonist
Alternative Names: ET-18-OCH3
Chemical Name: (7R)-4-Hydroxy-7-methoxy-N,N,N-trimethyl-3,5,9-trioxa-4-phosphaheptacosan-1-aminium-4-oxide
Biological Activity for Edelfosine
Edelfosine is a synthetic lysophospholipid analog that selectively inhibits phosphatidylinositol phospholipase C (IC50= 9.6 μM in fibroblasts and adenocarcinoma cells). Also acts as an agonist at platelet-activating factor (PAF) receptors. Antitumor lipid; selectively induces apoptosis in tumor cells, sparing normal cells.
Technical Data for Edelfosine
| M. Wt | 523.73 |
| Formula | C27H58NO6P |
| Storage | Store at -20°C |
| CAS Number | 77286-66-9 |
| PubChem ID | 6918215 |
| InChI Key | MHFRGQHAERHWKZ-HHHXNRCGSA-N |
| Smiles | CO[C@@H](COP(OCC[N+](C)(C)C)([O-])=O)COCCCCCCCCCCCCCCCCCC |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Edelfosine
References for Edelfosine
References are publications that support the biological activity of the product.
Powis et al (1992) Selective inhibition of phosphatidylinositol phospholipase C by cytotoxic ether lipid analogues. Cancer Res. 52 2835 PMID: 1316230
Aoki et al (1995) A radioreceptor binding assay for platelet-activating factor (PAF) using membranes from CHO cells expressing human PAF receptor. J.Immunol.Methods 186 225 PMID: 7594622
Shimizu et al (2007) Roles of brain phosphatidylinositol-specific phospholipase C and diacylglycerol lipase in centrally administered histamine-induced adrenomedullary outflow in rats. Eur.J.Pharmacol. 571 138 PMID: 17628524
Wong et al (2007) Phospholipase C and myosin light chain kinase inhibition define a common step in actin regulation during cytokinesis. BMC Cell Biol. 8 15 PMID: 17509155
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Keywords: Edelfosine, Edelfosine supplier, Selective, PI-PLC, inhibitors, inhibits, PAF, receptor, Phospholipases, C, Phosphoinositide-Specific, Esterases, Platelet-activating, Factor, Receptors, ET18OCH3, ET-18-OCH3, (PAF), Phospholipase, 3022, Tocris Bioscience
9 Citations for Edelfosine
Citations are publications that use Tocris products. Selected citations for Edelfosine include:
Korb et al (2013) Arc in the nucleus regulates PML-dependent GluA1 transcription and homeostatic plasticity. Nat Neurosci 16 874 PMID: 23749147
Lee et al (2012) The calcium-sensing receptor regulates the NLRP3 inflammasome through Ca2+ and cAMP. Nature 492 123 PMID: 23143333
Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Cancer Biol Ther 303 C467 PMID: 22700794
Ozkucur et al (2014) NHE3 phosphorylation via PKCη marks the polarity and orientation of directionally migrating cells. Cell Mol Life Sci 71 4653 PMID: 24788043
Zhao (2014) BDNF-endocannabinoid interactions at neocortical inhibitory synapses require phospholipase C signaling. J Neurophysiol 111 1008 PMID: 24335212
Yu et al (2017) PLCγ-dependent mTOR signalling controls IL-7-mediated early B cell development. Nat Commun 8 1457 PMID: 29133930
Ailte et al (2017) Exogenous lysophospholipids with large head groups perturb clathrin-mediated endocytosis. Traffic 18 176 PMID: 28067430
Liu et al (2015) A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. Sci Signal 8 ra71 PMID: 26198357
Pitt et al (2017) Neuroprotective astrocyte-derived Ins/IGF-1 stimulates endocytic processing and extracellular release of neuron-bound Aβ oligomers. Mol Biol Cell 28 2623 PMID: 28963439
Reviews for Edelfosine
Average Rating: 4 (Based on 1 Review.)
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works well.
By
Anonymous on 03/26/2020
Assay Type: In Vitro
Species: Rat
Cell Line/Tissue: Hippocampal neuron
10uM
