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Submit ReviewEIT hydrobromide
Description: Selective iNOS inhibitor, acts arginine binding site
Chemical Name: (S)-Ethylisothiourea hydrobromide
Biological Activity for EIT hydrobromide
Potent, selective and reversible inhibitor of isoform II NO synthase (IC50 = 13 nM; approximately 20- and 30-fold selective over isoforms I and III respectively).
Technical Data for EIT hydrobromide
| M. Wt | 185.08 |
| Formula | C3H8N2S.HBr |
| Storage | Store at RT |
| CAS Number | 1071-37-0 |
| PubChem ID | 200213 |
| InChI Key | SWXXKWPYNMZFTE-UHFFFAOYSA-N |
| Smiles | NC(SCC)=N.Br |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EIT hydrobromide
Certificate of Analysis is currently unavailable on-line.
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References for EIT hydrobromide
References are publications that support the biological activity of the product.
Garvey et al (1994) Potent and selective inhibition of human nitric oxide synthase. J.Biol.Chem. 269 26669 PMID: 7523409
Nakane et al (1995) Novel potent and selective inhibitors of inducible nitric oxide synthase. Mol.Pharmacol. 47 831 PMID: 7536889
Squadrito et al (1996) Effects of S-ethylisothiourea, a potent inhibitor of nitirc oxide synthase, alone or in combination with a nitric oxide donor in splanchnic artery occlusion shock. Br.J.Pharmacol. 119 23 PMID: 8872352
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Keywords: EIT hydrobromide, EIT hydrobromide supplier, Selective, iNOS, inhibitors, inhibits, arginine, binding, site, Nitric, Oxide, Signaling, Signalling, Inducible, NO, Synthases, 0873, Tocris Bioscience
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