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Submit ReviewEMDT oxalate
Description: Selective 5-HT6 agonist
Chemical Name: 2-Ethyl-5-methoxy-N,N-dimethyl-1H-indole-3-ethanamine oxalate
Purity: ≥98% (HPLC)
Biological Activity for EMDT oxalate
Selective 5-HT6 agonist (with a Ki value of 16 nM at human 5-HT6 receptors). Exhibits potency comparable to serotonin for the activation of adenylate cyclase. Displays antidepressant-like effects.
Technical Data for EMDT oxalate
| M. Wt | 336.38 |
| Formula | C15H22N2O.C2H2O4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 263744-72-5 |
| PubChem ID | 90488919 |
| InChI Key | IFGWAHGHGDZBEH-UHFFFAOYSA-N |
| Smiles | CCC2=C(CCN(C)C)C1=CC(OC)=CC=C1N2.O=C(C(O)=O)O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EMDT oxalate
References for EMDT oxalate
References are publications that support the biological activity of the product.
Glennon et al (2000) 2-Substituted tryptamines: Agents with selectivity for 5-HT6 serotonin receptors. J.Med.Chem. 43 1011 PMID: 10715164
Svenningsson et al (2007) Biochemical and behavioral evidence for antidepressant-like effects of 5-HT6 receptor stimulation. J.Neurosci. 27 4201 PMID: 17428998
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Currently there are no citations for EMDT oxalate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Alzheimer's Disease Poster
Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.