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Description: UBE2D degrader building block
Chemical Name: N-[[3-(3-Fluoro-4-hydroxyphenyl)-4,5-dihydro-5-isoxazolyl]methyl]-2-propenamide
Purity: ≥95% (HPLC)
Biological Activity for EN67, phenol
EN67, phenol is a UBE2D building block. It covalently binds with the allosteric C111 residue on E2 ubiquitin-conjugating enzymes UBE2D. It can be used in targeted protein degraders to degrade neo-substrate targets, including the target proteins BRD4 and androgen receptor, in a UBE2D-dependent manner.
Usage Guidelines for EN67, phenol
This product is provided for use in onward chemistry. Suitable solvents can be used.
Technical Data for EN67, phenol
| M. Wt | 264.26 |
| Formula | C13H13FN2O3 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| InChI Key | RCYKZLWHDJZATC-UHFFFAOYSA-N |
| Smiles | O=C(NCC1ON=C(C1)C2=CC(F)=C(O)C=C2)C=C |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for EN67, phenol
References for EN67, phenol
References are publications that support the biological activity of the product.
Forte et al (2023) Targeted Protein Degradation through E2 Recruitment. ACS Chem.Biol. 18 897 PMID: 36940189
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Keywords: EN67, phenol, EN67, phenol supplier, EN67, Phenol, degraders, degradation, targeted, protein, degrader, E3, ligase,, protac, Functionalized, BRD4, UBE2D, E2, ubiquitin, conjugating, enzyme, Ligase, Ligands, 8003, Tocris Bioscience
Citations for EN67, phenol
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Literature in this Area
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Targeted Protein Degradation Poster
Degraders (e.g. PROTACs) are bifunctional small molecules, that harness the Ubiquitin Proteasome System (UPS) to selectively degrade target proteins within cells. They consist of three covalently linked components: an E3 ubiquitin ligase ligand, a linker and a ligand for the target protein of interest. Authored in-house, this poster outlines the generation of a toolbox of building blocks for the development of Degraders. The characteristics and selection of each of these components are discussed. Presented at EFMC 2018, Ljubljana, Slovenia