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Submit ReviewEprosartan mesylate
Discontinued Product
4696 has been discontinued.
View all Angiotensin AT<sub>1</sub> Receptors products.
Description: Potent and selective AT1 receptor antagonist
Alternative Names: SK&F 108566
Chemical Name: (αE)-α-[[2-Butyl-1-[(4-carboxyphenyl)methyl]-1H-imidazol-5-yl]methylene]-2-thiophenepropanoic acid methanesulfonate
Purity: ≥99% (HPLC)
Biological Activity for Eprosartan mesylate
Potent angiotensin II receptor 1 (AT1) antagonist (IC50 values are 1.5, 1.7, 3.9 and 9.2 nM at rat mesenteric artery, human liver membrane, human adrenal cortical membrne and rat adrenal cortical membrane respectively). Displays no effect on vasopressin or CGRP binding, or angiotensin-converting enzyme (ACE) activity. Inhibits the angiotensin II-induced pressor response in normotensive rats.
Technical Data for Eprosartan mesylate
| M. Wt | 520.62 |
| Formula | C23H24N2O4S.CH3SO3H |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 144143-96-4 |
| PubChem ID | 5282474 |
| InChI Key | DJSLTDBPKHORNY-XMMWENQYSA-N |
| Smiles | CCCCC1=NC=C(/C=C(C(O)=O)\CC3=CC=CS3)N1CC2=CC=C(C(O)=O)C=C2.CS(=O)(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Eprosartan mesylate
References for Eprosartan mesylate
References are publications that support the biological activity of the product.
Oh et al (2011) Angiotensin II inhibits Ins binding to endothelial cells. Diabetes Metab.J. 35 243 PMID: 21785744
Edwards et al (1992) Pharmacological characterization of the nonpeptide angiotensin II receptor antagonist, SK&F 108566. J.Pharmacol.Exp.Ther. 260 175 PMID: 1309870
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Keywords: Eprosartan mesylate, Eprosartan mesylate supplier, SK&F, 108566, SK&F108566, angiotensin, II, AT1, receptors, antagonists, inhibits, potent, selective, competitive, Angiotensin, Receptors, 4696, Tocris Bioscience
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