Erastin

Cat. No. 5449 4 Citations Submit a Review Datasheet / COA / SDS

Pricing	Availability		Qty

Description: Mitochondrial VDAC modulator; also Ferroptosis activator

Chemical Name: 2-[1-[4-[2-(4-Chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-quinazolinone

Purity: ≥98% (HPLC)

Datasheet

Citations (4)

Reviews

Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for Erastin

Erastin is an antitumor agent; selective for cells expressing oncogenic RAS. Activates ferroptosis; induces oxidative, non-apoptotic cell death in tumors by modulating mitochondrial voltage-dependent anion channels (VDAC). Cell permeable.

Compound Libraries for Erastin

Erastin is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for Erastin

M. Wt	547.04
Formula	C₃₀H₃₁ClN₄O₄
Storage	Store at -20°C
Purity	≥98% (HPLC)
CAS Number	571203-78-6
PubChem ID	11214940
InChI Key	BKQFRNYHFIQEKN-UHFFFAOYSA-N
Smiles	O=C2C1=CC=CC=C1N=C(C(N4CCN(C(COC5=CC=C(Cl)C=C5)=O)CC4)C)N2C3=C(OCC)C=CC=C3

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for Erastin

	Solvent	Max Conc. mg/mL	Max Conc. mM
Solubility
Solubility	DMSO	10.94	20

Preparing Stock Solutions for Erastin

The following data is based on the product molecular weight 547.04. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.2 mM	9.14 mL	45.7 mL	91.4 mL
1 mM	1.83 mL	9.14 mL	18.28 mL
2 mM	0.91 mL	4.57 mL	9.14 mL
10 mM	0.18 mL	0.91 mL	1.83 mL

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Product Datasheets for Erastin

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Erastin

References are publications that support the biological activity of the product.

Dolma et al (2003) Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells. Cancer Cell 3 285 PMID: 12676586

Yagoda et al (2007) RAS-RAF-MEK-dependent oxidative cell death involving voltage-dependent anion channels. Nature 447 864 PMID: 17568748

Dixon et al (2012) Ferroptosis: an iron-dependent form of nonapoptotic cell death. Cell 149 1060 PMID: 22632970

If you know of a relevant reference for Erastin, please let us know.

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