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ESI 05

Cat. No. 6320 Submit a Review Datasheet / COA / SDS
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Description: Epac2 inhibitor
Chemical Name: 1,3,5-Trimethyl-2-[(4-methylphenyl)sulfonyl]benzene
Purity: ≥98% (HPLC)
Datasheet
Citations
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Biological Activity Technical Data Solubility Calculators Datasheets References

Biological Activity for ESI 05

ESI 05 is an EPAC2 inhibitor. Inhibits cAMP binding to EPAC2 and cAMP mediated EPAC2 guanine nucleotide exchange factor (GEF) activity (IC50 = 0.4 μM).

Compound Libraries for ESI 05

ESI 05 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.

Technical Data for ESI 05

M. Wt 274.38
Formula C16H18O2S
Storage Store at RT
Purity ≥98% (HPLC)
CAS Number 5184-64-5
PubChem ID 272513
InChI Key CGPHOZWFSFNOEQ-UHFFFAOYSA-N
Smiles CC1=CC=C(S(=O)(C2=C(C=C(C=C2C)C)C)=O)C=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Solubility Data for ESI 05

Solvent Max Conc. mg/mL Max Conc. mM
Solubility
DMSO 27.44 100
ethanol 27.44 100

Preparing Stock Solutions for ESI 05

The following data is based on the product molecular weight 274.38. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.

Select a batch to recalculate based on the batch molecular weight:
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
1 mM 3.64 mL 18.22 mL 36.45 mL
5 mM 0.73 mL 3.64 mL 7.29 mL
10 mM 0.36 mL 1.82 mL 3.64 mL
50 mM 0.07 mL 0.36 mL 0.73 mL

Molarity Calculator

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Reconstitution Calculator

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Dilution Calculator

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References for ESI 05

References are publications that support the biological activity of the product.

Tsalkova et al (2012) Isoform-specific antagonists of exchange proteins directly activated by cAMP. Proc.Natl.Acad.Sci.USA. 109 18613 PMID: 23091014

If you know of a relevant reference for ESI 05, please let us know.

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Citations for ESI 05

Citations are publications that use Tocris products.

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