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Submit ReviewEtifoxine hydrochloride
Description: Ligand of the translocator protein (TSPO); also GABAA receptor potentiator
Chemical Name: 6-Chloro-2-N-ethyl-4-methyl-4-phenyl-4H-3,1-benzoxazin-2-amine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Etifoxine hydrochloride
Etifoxine hydrochloride is a potentiator of GABAA receptor function in cultured neurons. Preferentially acts on β2 or β3 subunit-containing GABAA receptors. Exhibits anxiolytic activity in rodents and humans with no sedative, myorelaxant or mnesic side effects. Acts as a ligand of the translocator protein (TSPO); promotes axonal regeneration.
Compound Libraries for Etifoxine hydrochloride
Etifoxine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Etifoxine hydrochloride
| M. Wt | 337.24 |
| Formula | C17H17ClN2O.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 56776-32-0 |
| PubChem ID | 171544 |
| InChI Key | SCBJXEBIMVRTJE-UHFFFAOYSA-N |
| Smiles | CCNC2=NC1=CC=C(Cl)C=C1C(C3=CC=CC=C3)(C)O2.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Etifoxine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.72 | 100 |
Preparing Stock Solutions for Etifoxine hydrochloride
The following data is based on the product molecular weight 337.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.97 mL | 14.83 mL | 29.65 mL |
| 5 mM | 0.59 mL | 2.97 mL | 5.93 mL |
| 10 mM | 0.3 mL | 1.48 mL | 2.97 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.59 mL |
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Product Datasheets for Etifoxine hydrochloride
References for Etifoxine hydrochloride
References are publications that support the biological activity of the product.
Hamon et al (2003) The modulatory effects of the anxiolytic etifoxine on GABAA receptors are mediated by the β subunit. Neuropharmacology 45 293 PMID: 12871647
Girard et al (2008) Etifoxine improves peripheral nerve regeneration and functional recovery. Proc.Natl.Acad.Sci. 105 20505 PMID: 19075249
If you know of a relevant reference for Etifoxine hydrochloride, please let us know.
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Citations for Etifoxine hydrochloride
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