Famotidine

Discontinued Product

7290 has been discontinued.

View all Histamine H<sub>2</sub> Receptors products.
Description: Potent and high affinity H2 biased inverse agonist
Chemical Name: 3-[[[2-[(Aminoiminomethyl)amino]-4-thiazolyl]methyl]thio]-N-(aminosulfonyl)propanimidamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (1)

Biological Activity for Famotidine

Famotidine is a potent and high affinity histamine H2 receptor biased inverse agonist (Kd = 14 nM, IC50 = 33 nM). Reduces basal receptor activity by 75%. Inhibits Gs-mediated pathways but acts as a partial agonist of β-arrestin recruitment (EC50 = 105 nM). Inhibits gastric acid secretion and histamine-induced mast cell activation. Also inhibits HIV replication in vitro.

Technical Data for Famotidine

M. Wt 337.44
Formula C8H15N7O2S3
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 76824-35-6
PubChem ID 3325
InChI Key XUFQPHANEAPEMJ-UHFFFAOYSA-N
Smiles NC(=N)NC1=NC(CSCCC(=N)N[S](N)(=O)=O)=CS1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Famotidine

References are publications that support the biological activity of the product.

Takagi et al (1982) Effect of a new potent H2-blocker, 3-[[[2-[(diaminomethylene)amino]-4-thiazolyl]methyl]-thio]-N2-sulfamoylpropionamidine (YM-11170) on gastric secretion induced by histamine and food in conscious dogs. Arch.Int.Pharmacodyn.Ther. 256 49 PMID: 6124219

Pendleton et al (1985) Effects of H2-receptor antagonists upon physiological acid secretory states in animals. J.Pharmacol.Exp.Ther. 233 64 PMID: 2858583

Bourinbaiar & Fruhstorfer (1996) The effect of histamine type 2 receptor antagonists on human immunodeficiency virus (HIV) replication: identification of a new class of antiviral agents. Life Sci. 59 365 PMID: 8950301

Malone et al (2020) COVID-19: Famotidine, histamine, mast cells, and mechanisms. Res.Sq. - Paper not yet peer reviewed PMID: 32702719

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Keywords: Famotidine, Famotidine supplier, YM, 11170, MK, 208, histamine, h2, receptor, inverse, agonists, antagonists, biased, signaling, antiviral, COVID-19, mast, cell, activation, Histamine, H2, Receptors, HIV, 7290, Tocris Bioscience

Citations for Famotidine

Citations are publications that use Tocris products.

Currently there are no citations for Famotidine.

Reviews for Famotidine

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

*Please note that Tocris will only send literature to established scientific business / institute addresses.


Histamine Receptors Scientific Review

Histamine Receptors Scientific Review

Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.