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Description: GLUT1/GLUT4 inhibitor; also Fas-sensitizer
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity: ≥98% (HPLC)
Biological Activity for Fasentin
Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.
Technical Data for Fasentin
| M. Wt | 279.64 |
| Formula | C11H9ClF3NO2 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 392721-37-8 |
| PubChem ID | 879520 |
| InChI Key | GNYIJZMBLZXJEJ-UHFFFAOYSA-N |
| Smiles | CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fasentin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.96 | 100 | |
| ethanol | 27.96 | 100 |
Preparing Stock Solutions for Fasentin
The following data is based on the product molecular weight 279.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.58 mL | 17.88 mL | 35.76 mL |
| 5 mM | 0.72 mL | 3.58 mL | 7.15 mL |
| 10 mM | 0.36 mL | 1.79 mL | 3.58 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
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Product Datasheets for Fasentin
References for Fasentin
References are publications that support the biological activity of the product.
Schimmer et al (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 66 2367 PMID: 16489043
Wood et al (2008) A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 7 3546 PMID: 19001437
Granchi et al (2016) Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 7 1716 PMID: 28042452
If you know of a relevant reference for Fasentin, please let us know.
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Keywords: Fasentin, Fasentin supplier, Fasentin, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, Fas-sensitizer, apoptosis, TNF, Transporters, 6100, Tocris Bioscience
Citations for Fasentin
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