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Fasentin

Cat. No. 6100 Submit a Review Datasheet / COA / SDS

Discontinued Product

6100 has been discontinued.

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Description: GLUT1/GLUT4 inhibitor; also Fas-sensitizer
Chemical Name: N-(4-Chloro-3-(trifluoromethyl)phenyl)-3-oxobutanamide
Purity: ≥98% (HPLC)
Datasheet
Citations
Reviews
Literature (2)
Biological Activity Technical Data Datasheets References

Biological Activity for Fasentin

Fasentin is a GLUT1 and GLUT4 inhibitor (IC50 = 68 μM). Preferentially inhibits GLUT4 over GLUT1. Sensitizes Fas receptor in a range of tumor cell lines (IC50 = 20 μM) by modulating the extrinsic apoptotic pathway downstream of TNF receptors but upstream of effector caspases.

Technical Data for Fasentin

M. Wt 279.64
Formula C11H9ClF3NO2
Storage Store at -20°C
Purity ≥98% (HPLC)
CAS Number 392721-37-8
PubChem ID 879520
InChI Key GNYIJZMBLZXJEJ-UHFFFAOYSA-N
Smiles CC(CC(NC1=CC(C(F)(F)F)=C(C=C1)Cl)=O)=O

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

References for Fasentin

References are publications that support the biological activity of the product.

Schimmer et al (2006) Identification of small molecules that sensitize resistant tumor cells to tumor necrosis factor-family death receptors. Cancer.Res. 66 2367 PMID: 16489043

Wood et al (2008) A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol.Cancer.Ther. 7 3546 PMID: 19001437

Granchi et al (2016) Anticancer agents interacting with membrane glucose transporters. Med.Chem.Comm. 7 1716 PMID: 28042452

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Keywords: Fasentin, Fasentin supplier, Fasentin, Inhibitors, Inhibits, Glucose, transporter, GLUT1, GLUT4, Fas-sensitizer, apoptosis, TNF, Transporters, 6100, Tocris Bioscience

Citations for Fasentin

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Currently there are no citations for Fasentin.

Reviews for Fasentin

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Literature in this Area

Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!

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Cancer Metabolism Poster

Cancer Metabolism Poster

This poster summarizes the main metabolic pathways in cancer cells and highlights potential targets for cancer therapeutics. Genetic changes and epigenetic modifications in cancer cells alter the regulation of cellular metabolic pathways providing potential cancer therapeutic targets.