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Submit ReviewFelodipine
Discontinued Product
2960 has been discontinued.
View all Ca<sub>V</sub>1.x Channels (L-type) products.
Description: CaV1.x blocker
Chemical Name: 4-(2,3-Dichlorophenyl)-1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylic acid ethyl methyl ester
Purity: ≥98% (HPLC)
Biological Activity for Felodipine
Felodipine is a L-type Ca2+ channel blocker that is selective over N-, R-, P/Q- and T-type channels. Displays high vascular selectivity; lowers arterial blood pressure without altering cardiac contractility. Antihypertensive.
Compound Libraries for Felodipine
Felodipine is also offered as part of the Tocriscreen FDA-Approved Drugs. Find out more about compound libraries available from Tocris.
Technical Data for Felodipine
| M. Wt | 384.25 |
| Formula | C18H19Cl2NO4 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 72509-76-3 |
| PubChem ID | 3333 |
| InChI Key | RZTAMFZIAATZDJ-UHFFFAOYSA-N |
| Smiles | ClC1=C(Cl)C(C2C(C(OC)=O)=C(C)NC(C)=C2C(OCC)=O)=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Felodipine
References for Felodipine
References are publications that support the biological activity of the product.
Ljung (1990) Vascular selectivity of felodipine: experimental pharmacology. J.Cardiovasc.Pharmacol. 15 S11 PMID: 1693715
Furukawa et al (1999) Selectivities of dihydropyridine derivatives in blocking Ca2+ channel subtypes expressed in Xenopus oocytes. J.Pharmacol.Exp.Ther. 291 464 PMID: 10525060
Furukawa et al (2005) Differential blocking action of dihydropyridine Ca2+ antagonists on a T-type Ca2+ channel (α1G) expressed in Xenopus oocytes. J.Cardiovasc.Pharmacol. 45 241 PMID: 15725949
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Keywords: Felodipine, Felodipine supplier, Ca2+, channel, blockers, L-type, Calcium, CaV, Channels, L-Type, voltage-gated, voltage-dependent, Cav1.x, 2960, Tocris Bioscience
Citations for Felodipine
Citations are publications that use Tocris products.
Currently there are no citations for Felodipine.
Reviews for Felodipine
Average Rating: 5 (Based on 1 Review.)
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Felodipine used on Cav1.2 channels.
By
Anonymous on 02/04/2019
Species: Human
Felodipine used on Cav1.2 channels to see the effect on blocking with increasing concentration and the underlying mechanism involved.
