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Submit ReviewFisetin
Description: Naturally occuring flavonoid and antioxidant; neuroprotective
Chemical Name: 2-(3,4-Dihydroxyphenyl)-3,7-dihydroxy-4H-1-benzopyran-4-one
Purity: ≥97% (HPLC)
Biological Activity for Fisetin
Fisetin is a naturally occuring flavonoid and antioxidant. Inhibits PI 3-K, Akt, mTOR and Cdk6. Displays antiproliferative activity in prostate cancer cells. Shown to activate ERK; exhibits neuroprotective activity in Huntington's disease models. Also a DNMT1 inhibitor.
Technical Data for Fisetin
| M. Wt | 286.24 |
| Formula | C15H10O6 |
| Storage | Store at -20°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 528-48-3 |
| PubChem ID | 5281614 |
| InChI Key | XHEFDIBZLJXQHF-UHFFFAOYSA-N |
| Smiles | OC2=C(C3=CC=C(O)C(O)=C3)OC1=CC(O)=CC=C1C2=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Fisetin
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 28.62 | 100 | |
| ethanol | 2.86 | 10 |
Preparing Stock Solutions for Fisetin
The following data is based on the product molecular weight 286.24. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.49 mL | 17.47 mL | 34.94 mL |
| 5 mM | 0.7 mL | 3.49 mL | 6.99 mL |
| 10 mM | 0.35 mL | 1.75 mL | 3.49 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.7 mL |
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Product Datasheets for Fisetin
References for Fisetin
References are publications that support the biological activity of the product.
Lu et al (2005) Crystal structure of a human cyclin-dependent kinase 6 complex with a flavonol inhibitor, fisetin. J.Med.Chem. 48 737 PMID: 15689157
Adhami et al (2012) Dietary flavonoid fisetin: a novel dual inhibitor of PI3K/Akt and mTOR for prostate cancer management. Biochem.Pharmacol. 84 1277 PMID: 22842629
Haddad et al (2010) Antiproliferative mechanisms of the flavonoids 2,2'-dihydroxychalcone and fisetin in human prostate cancer cells. Nutr.Cancer 62 668 PMID: 20574928
Maher et al (2011) ERK activation by the polyphenols fisetin and resveratrol provides neuroprotection in multiple models of Huntington's disease. Hum.Mol.Genet. 20 261 PMID: 20952447
Lee et al (2005) Mechanisms for the inhibition of DNA methyltransferases by tea catechins and bioflavonoids. Mol.Pharmacol. 68 1018 PMID: 16037419
If you know of a relevant reference for Fisetin, please let us know.
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Keywords: Fisetin, Fisetin supplier, flavonoids, antioxidants, inhibitors, inhibits, PI, 3-K, kinase, Akt, mTOR, Cdk6, antiproliferative, cancer, activates, ERK, neuroprotective, Huntington's, DNA, Methyltransferases, DNMT, Antioxidants, 5016, Tocris Bioscience
4 Citations for Fisetin
Citations are publications that use Tocris products. Selected citations for Fisetin include:
Alun M et al (2021) How CD40L reverse signaling regulates axon and dendrite growth. Cell Mol Life Sci 78 1065-1083 PMID: 32506167
Alun M et al (2021) Signalling Pathways Mediating the Effects of CD40-Activated CD40L Reverse Signalling on Inhibitory Medium Spiny Neuron Neurite Growth. Cells 10 PMID: 33917019
Young Ho et al (2021) A splicing variant of TFEB negatively regulates the TFEB-autophagy pathway. Sci Rep 11 21119 PMID: 34702966
Kim et al (2016) Fisetin stimulates autophagic degradation of phosphorylated tau via the activation of TFEB and Nrf2 transcription factors. PLoS Pathog 6 24933 PMID: 27112200
Do you know of a great paper that uses Fisetin from Tocris? Please let us know.
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