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Submit ReviewFLI 06
Description: Inhibitor of Notch signaling; disrupts Notch trafficking and processing
Chemical Name: Cyclohexyl 1,4,5,6,7,8-hexahydro-2,7,7-trimethyl-4-(4-nitrophenyl)-5-oxo-3-quinolinecarboxylate
Purity: ≥99% (HPLC)
Biological Activity for FLI 06
FLI 06 is an inhibitor of Notch signaling (EC50 = 2.3 μM). Disrupts Notch trafficking and processing. Reduces amyloid β secretion. Changes the maturation and abolishes shredding of APP. Inhibits ER exporting and converts tubular ER to sheets.
Technical Data for FLI 06
| M. Wt | 438.52 |
| Formula | C25H30N2O5 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 313967-18-9 |
| PubChem ID | 3103157 |
| InChI Key | SWWVFYHSSOWZMF-UHFFFAOYSA-N |
| Smiles | O=C(OC3CCCCC3)C1=C(C)NC(CC(C)(C)CC4=O)=C4C1C2=CC=C([N+]([O-])=O)C=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for FLI 06
References for FLI 06
References are publications that support the biological activity of the product.
Krämer et al (2013) Small molecules intercept Notch signaling and the early secretory pathway. Nat.Chem.Biol. 9 731 PMID: 24077179
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Keywords: FLI 06, FLI 06 supplier, FLI06, inhibitors, inhibits, Notch, signalling, amyloid, μ, beta, Other, Signaling, Translocation, 5172, Tocris Bioscience
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