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Description: Induces ferroptosis; inhibits FSP1
Chemical Name: 3-(4-Bromophenyl)-6-((4-(4-methoxyphenyl)piperazin-1-yl)methyl)thiazolo[2,3-c][1,2,4]triazole
Purity: ≥98% (HPLC)
Biological Activity for FSEN 1
FSEN 1 is a ferroptosis suppressor protein 1 (FSP1) inhibitor (IC50 = 313 nM). FSEN 1 sensitizes lung cancer cells and organoids to ferroptosis (EC50 = 69 nM) through inhibition of FSP1. Inhibits FSP1 CoQ1 oxidoreductase activity (IC50 = 688 nM).
Technical Data for FSEN 1
| M. Wt | 484.42 |
| Formula | C22H22BrN5OS |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 862808-01-3 |
| PubChem ID | 22583648 |
| InChI Key | JGXIXBKKDUNARN-UHFFFAOYSA-N |
| Smiles | BrC1=CC=C(C2=NN=C3SC(CN4CCN(CC4)C5=CC=C(C=C5)OC)=CN32)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for FSEN 1
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 9.69 | 20 |
Preparing Stock Solutions for FSEN 1
The following data is based on the product molecular weight 484.42. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 10.32 mL | 51.61 mL | 103.22 mL |
| 1 mM | 2.06 mL | 10.32 mL | 20.64 mL |
| 2 mM | 1.03 mL | 5.16 mL | 10.32 mL |
| 10 mM | 0.21 mL | 1.03 mL | 2.06 mL |
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Product Datasheets for FSEN 1
References for FSEN 1
References are publications that support the biological activity of the product.
Hendricks et al (2023) Identification of structurally diverse FSP1 inhibitors that sensitize cancer cells to ferroptosis. Cell Chem.Biol. 30 1090 PMID: 37178691
If you know of a relevant reference for FSEN 1, please let us know.
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Keywords: FSEN 1, FSEN 1 supplier, FSEN1, ferroptosis, sensititizer, 1, suppressor, protein, FSP1, CoQ1, lung, cancer, Ferroptosis, 7941, Tocris Bioscience
Citations for FSEN 1
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
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MAPK Signaling Scientific Review
MAP kinase signaling is integral to the regulation of numerous cellular processes such as proliferation and differentiation, and as a result is an important focus of cancer and immunology research. Updated for 2016, this review discusses the regulation of the MAPK pathway and properties of MAPK cascades. Compounds available from Tocris are listed.
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Alzheimer's disease (AD) is a debilitating and progressive neurodegenerative disease and the most common cause of dementia, affecting approximately 30% of individuals aged over 85 years. This poster summarizes the cellular and molecular mechanisms of AD.
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Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.
Pathways for FSEN 1
