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Submit ReviewFumitremorgin C
Description: Inhibitor of BCRP-mediated multidrug resistance
Chemical Name: (5aS,12S,14aS)-1,2,3,5a,6,11,12,14a-Octahydro-9-methoxy-12-(2-methyl-1-propen-1-yl)-5H,14H-pyrrolo[1'',2'':4',5']pyrazino[1',2':1,6]pyrido[3,4-b]indole-5,14-dione
Purity: ≥98% (HPLC)
Biological Activity for Fumitremorgin C
Fumitremorgin C is a chemosensitizing agent; selectively reverses BCRP-mediated multidrug resistance to mitoxantrone (Cat. No. 4250), doxorubicin (Cat. No. 2252) and topotecan (Cat. No. 4562) in transfected MCF-7 cells. Does not reverse resistance in P-gp- or MRP-positive cells. Analog (Ko 143, Cat. No. 3241) also available.
Technical Data for Fumitremorgin C
| M. Wt | 379.45 |
| Formula | C22H25N3O3 |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 118974-02-0 |
| PubChem ID | 403923 |
| InChI Key | DBEYVIGIPJSTOR-FHWLQOOXSA-N |
| Smiles | O=[C@@]3N5[C@@H](CCC5)C(N([C@H]3C4)[C@@H](/C=C(C)/C)C2=C4C1=CC=C(OC)C=C1N2)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Fumitremorgin C
References for Fumitremorgin C
References are publications that support the biological activity of the product.
Rabindran et al (2000) Fumitremorgin C reverses multidrug resistance in cells transfected with the breast cancer resistance protein. Cancer Res. 60 PMID: 10646850
Rabindran et al (1998) Reversal of a novel multidrug resistance mechanism in human colon carcinoma cells by fumitremorgin C. Cancer Res. 58 5850 PMID: 9865745
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Keywords: Fumitremorgin C, Fumitremorgin C supplier, mycotoxins, chemosensitisers, chemosensitizers, chemosensitizing, chemosensitising, BCRP, breast, cancer, resistance, proteins, reverses, multidrug, MDR, FumitremorginC, Multidrug, Transporters, 2876, Tocris Bioscience
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