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Description: Activator of STING-dependent signaling
Chemical Name: 4-[(2-Chloro-6-fluorophenyl)methyl]-N-(2-furanylmethyl)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine-6-carboxamide
Purity: ≥98% (HPLC)
Biological Activity for G10
G10 is an activator of STING-dependent signaling; exhibits no direct binding affinity for STING. Stimulates IRF-3-induced transcription and induces IFNα and IFNγ gene expression in human fibroblasts. Exhibits no effect on NF-κB signaling. Blocks viral replication in vitro.
Compound Libraries for G10
G10 is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for G10
| M. Wt | 430.88 |
| Formula | C21H16ClFN2O3S |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 702662-50-8 |
| PubChem ID | 5077622 |
| InChI Key | NAGKYJATVFXZKN-UHFFFAOYSA-N |
| Smiles | FC1=CC=CC(Cl)=C1CN2C(CSC3=CC=C(C(NCC4=CC=CO4)=O)C=C23)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for G10
References for G10
References are publications that support the biological activity of the product.
Sali et al (2015) Characterization of a novel human-specific STING agonist that elicits antiviral activity against emerging alphaviruses. PLoS Pathog. 11 e1005324 PMID: 26646986
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Keywords: G10, G10 supplier, STING-dependent, signaling, activators, activates, interferons, IRF3, antiviral, STING-Dependent, Signaling, 5944, Tocris Bioscience
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