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Submit ReviewGMQ hydrochloride
Description: Selective ASIC3 opener
Chemical Name: N-(4-Methyl-2-quinazolinyl)-guanidine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for GMQ hydrochloride
GMQ hydrochloride is a selective opener of acid-sensing ion channel 3 (ASIC3) at pH 7.4. Alters the pH dependence of ASIC1a and ASIC1b; does not affect the activation curve of ASIC2a.
Technical Data for GMQ hydrochloride
| M. Wt | 237.69 |
| Formula | C10H11N5.HCl |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 5361-15-9 |
| PubChem ID | 12253739 |
| InChI Key | VNPZWQRWOHFAPD-UHFFFAOYSA-N |
| Smiles | CC2=NC(NC(N)=N)=NC1=CC=CC=C12.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GMQ hydrochloride
References for GMQ hydrochloride
References are publications that support the biological activity of the product.
Alijevic and Kellenberger (2012) Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazoline. J.Biol.Chem. 287 36059 PMID: 22948146
Li et al (2010) ASIC3 channels integrate agmatine and multiple inflammatory signals through the nonproton ligand sensing domain. Mol.Pain 6 88 PMID: 21143836
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Keywords: GMQ hydrochloride, GMQ hydrochloride supplier, Selective, opener, acid-sensing, ion, channel, 3, ASIC3, ASIC1a, ASIC1b, ASIC, 5028, Tocris Bioscience
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