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Description: Positive allosteric modulator of NMDA receptors; acts in transmembrane domain
Chemical Name: 4-Cyclohexyl-N-(7-hydroxy-5-methyl-2-propyl[1,2,4]triazolo[1,5-a]pyrimidin-6-yl)benzenesulfonamide
Purity: ≥98% (HPLC)
Biological Activity for GNE 9278
GNE 9278 is a positive allosteric modulator of NMDA receptors. Potentiates NMDA receptors containing GluN2A, 2B, 2C and 2D subunits (EC50 values are 0.74, 3.07, 0.47 and 0.32 μM in a Ca2+ influx assay, respectively). Binds within the transmembrane domain and displays preference for agonist-bound NMDA receptors. Slows receptor deactivation and enhances the potency of glutamate and glycine.
Compound Libraries for GNE 9278
GNE 9278 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for GNE 9278
| M. Wt | 429.54 |
| Formula | C21H27N5O3S |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 901230-11-3 |
| PubChem ID | 22432385 |
| InChI Key | OKXCVUICUUOADN-UHFFFAOYSA-N |
| Smiles | OC(N1C2=NC(CCC)=N1)=C(C(C)=N2)N[S](=O)(C3=CC=C(C4CCCCC4)C=C3)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for GNE 9278
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 42.95 | 100 |
Preparing Stock Solutions for GNE 9278
The following data is based on the product molecular weight 429.54. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.33 mL | 11.64 mL | 23.28 mL |
| 5 mM | 0.47 mL | 2.33 mL | 4.66 mL |
| 10 mM | 0.23 mL | 1.16 mL | 2.33 mL |
| 50 mM | 0.05 mL | 0.23 mL | 0.47 mL |
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Product Datasheets for GNE 9278
References for GNE 9278
References are publications that support the biological activity of the product.
Wang et al (2017) A novel NMDA receptor positive allosteric modulator that acts via the transmembrane domain. Neuropharmacology. 121 204 PMID: 28457974
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Keywords: GNE 9278, GNE 9278 supplier, GNE9278, NMDA, receptor, positive, allosteric, modulators, modulates, PAM, GluN2A, GluN2B, GluN2C, GluN2D, Receptors, 6369, Tocris Bioscience
Citations for GNE 9278
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