Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewGolgicide A
Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF
Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline
Purity: ≥98% (HPLC)
Biological Activity for Golgicide A
Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.
Technical Data for Golgicide A
| M. Wt | 284.3 |
| Formula | C17H14F2N2 |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 1139889-93-2 |
| PubChem ID | 25113626 |
| InChI Key | NJZHEQOUHLZCOX-FTLRAWMYSA-N |
| Smiles | FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Golgicide A
References for Golgicide A
References are publications that support the biological activity of the product.
Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157
View Related Products by Target
View Related Products by Product Action
Keywords: Golgicide A, Golgicide A supplier, potent, specific, reversible, inhibitors, inhibits, Golgi, BFA, resistance, factors, 1, GBF1, ArfGEF, ADP, ribosylation, factor, guanine, nucleotide, exchange, Arf, Translocation, 3584, Tocris Bioscience
5 Citations for Golgicide A
Citations are publications that use Tocris products. Selected citations for Golgicide A include:
Marta et al (2019) Oncogenic dependence of glioma cells on kish/TMEM167A regulation of vesicular trafficking. Glia 67 404-417 PMID: 30506943
Ryan T et al (2019) VEGAS as a Platform for Facile Directed Evolution in Mammalian Cells. Cell 178 748-761.e17 PMID: 31280962
Krokowski (2017) GADD34 function in protein trafficking promotes adaptation to hyperosmotic stress in human corneal cells. Cell Rep 21 2895 PMID: 29212034
Gomes-da-Silva et al (2019) Recruitment of LC3 to damaged Golgi apparatus. Cell Death Differ 26 1467 PMID: 30349077
Guido et al (2021) Oleate-induced aggregation of LC3 at the trans-Golgi network is linked to a protein trafficking blockade. Cell Death Differ 28 1733-1752 PMID: 33335289
Reviews for Golgicide A
There are currently no reviews for this product. Be the first to review Golgicide A and earn rewards!
Have you used Golgicide A?
Submit a review and receive an Amazon gift card.
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image