Golgicide A

Name: Golgicide A
Brand: Tocris Bioscience
SKU: 3584

Cat. No. 3584 5 Citations Submit a Review Datasheet / COA / SDS

Discontinued Product

3584 has been discontinued.

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Description: Potent, selective and reversible inhibitor of GBF1 ArfGEF

Chemical Name: 6,8-Difluoro-4-pyridin-3-yl-3a,4,5,9b-tetrahydro-3H-cyclopenta[c]quinoline

Purity: ≥98% (HPLC)

Datasheet

Citations (5)

Reviews

Biological Activity Technical Data Datasheets References

Biological Activity for Golgicide A

Golgicide A is a potent, specific and reversible inhibitor of Golgi BFA resistance factor 1 (GBF1), an ArfGEF, that decreases Arf1 activation in vivo. Arrests secretion of soluble and membrane-associated proteins at the endoplasmic reticulum-Golgi intermediate compartment. Causes disassembly and dispersal of the Golgi and trans-Golgi network.

Technical Data for Golgicide A

M. Wt	284.3
Formula	C₁₇H₁₄F₂N₂
Storage	Store at RT
Purity	≥98% (HPLC)
CAS Number	1139889-93-2
PubChem ID	25113626
InChI Key	NJZHEQOUHLZCOX-FTLRAWMYSA-N
Smiles	FC4=CC([C@]3([H])[C@]([H])2CC=C3)=C(C(F)=C4)NC2C1=CN=CC=C1

The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.

Tocris products are intended for laboratory research use only, unless stated otherwise.

Product Datasheets for Golgicide A

Certificate of Analysis / Product Datasheet

Safety Datasheet

References for Golgicide A

References are publications that support the biological activity of the product.

Saenz et al (2008) Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nature Chem.Biol. 5 157

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