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Submit ReviewGR 32191 hydrochloride
Description: Potent thromboxane A2/TP receptor antagonist
Alternative Names: Vapiprost
Chemical Name: (4Z)-7-[(1R,2R,3S,5S)-5-([1,1'-Biphenyl]-4-ylmethoxy)-3-hydroxy-2-(1-piperidinyl)cyclopentyl]-4-heptenoic acid hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for GR 32191 hydrochloride
Potent thromboxane A2 (TP) receptor antagonist. Inhibits platelet aggregation (pA2 ~ 8.3) and relaxes vascular and airway smooth muscle (pA2 = 7.9 - 10.3).
Licensing Information
Sold for research purposes under agreement from GlaxoSmithKline
Technical Data for GR 32191 hydrochloride
| M. Wt | 514.1 |
| Formula | C30H39NO4.HCl |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 85505-64-2 |
| Smiles | Cl[H].O[C@H]1C[C@H](OCC2=CC=C(C=C2)C2=CC=CC=C2)[C@H](CC\C=C/CCC(O)=O)[C@H]1N1CCCCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GR 32191 hydrochloride
References for GR 32191 hydrochloride
References are publications that support the biological activity of the product.
Lumley et al (1989) GR32191, a highly potent and specific thromboxane A2 receptor blocking drug on platelets and vascular and airways smooth muscle in vitro. Br.J.Pharmacol. 97 783 PMID: 2527074
Ogletree and Allen (1992) Interspecies differences in thromboxane receptors: studies with thromboxane receptor antagonists in rat and guinea pig smooth muscles. J.Pharmacol.Exp.Ther. 260 789 PMID: 1531361
Takahara et al (1990) The response to thromboxane A2 analogues in human platelets. J.Biol.Chem. 265 6836 PMID: 2139029
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