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Submit ReviewGuanfacine hydrochloride
Description: α2A agonist
Chemical Name: [(2,6-Dichlorophenyl)acetyl]guanidine hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Guanfacine hydrochloride
Guanfacine hydrochloride is a selective α2A-adrenoceptor agonist (Kd = 31 nM). Displays 60-fold selectivity over α2B-adrenoceptors.
Technical Data for Guanfacine hydrochloride
| M. Wt | 282.56 |
| Formula | C9H9Cl2N3O.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 29110-48-3 |
| PubChem ID | 71401 |
| InChI Key | DGFYECXYGUIODH-UHFFFAOYSA-N |
| Smiles | Cl.NC(=N)NC(=O)CC1=C(Cl)C=CC=C1Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Guanfacine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 28.26 | 100 | |
| DMSO | 28.26 | 100 |
Preparing Stock Solutions for Guanfacine hydrochloride
The following data is based on the product molecular weight 282.56. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.54 mL | 17.7 mL | 35.39 mL |
| 5 mM | 0.71 mL | 3.54 mL | 7.08 mL |
| 10 mM | 0.35 mL | 1.77 mL | 3.54 mL |
| 50 mM | 0.07 mL | 0.35 mL | 0.71 mL |
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Product Datasheets for Guanfacine hydrochloride
References for Guanfacine hydrochloride
References are publications that support the biological activity of the product.
Intengan and Smyth (1997) Alpha-2a/d adrenoceptor subtype stimulation by guanf. increases osmolar clearance. J.Pharmacol.Exp.Ther. 281 48 PMID: 9103479
Uhlen and Wikberg (1991) Delineation of rat kidney α2A- and α2B-adrenoceptors with [3H]RX821002 radioligand binding: computer modelling reveals that guanf. is an α2A -selective compound. Eur.J.Pharmacol. 202 235 PMID: 1666366
Merck Index 12 4590
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Keywords: Guanfacine hydrochloride, Guanfacine hydrochloride supplier, α2A-adrenoceptor, alpha2A-adrenoceptor, a2a-adrenoceptor, a2a-adrenergic, α2a-adrenergic, alpha2a-adrenergic, agonists, Receptors, Adrenergic, Alpha-2, 1030, Tocris Bioscience
4 Citations for Guanfacine hydrochloride
Citations are publications that use Tocris products. Selected citations for Guanfacine hydrochloride include:
Shields et al (2009) alpha2A-adrenergic receptors heterosynaptically regulate glutamatergic transmission in the bed nucleus of the stria terminalis. Neuroscience 163 339 PMID: 19527774
Harris et al (2018) Dorsal BNST α2A-Adrenergic Receptors Produce HCN-Dependent Excitatory Actions That Initiate Anxiogenic Behaviors. J Neurosci 38 8922 PMID: 30150361
Hamby et al (2012) Inflammatory mediators alter the astrocyte transcriptome and calcium signaling elicited by multiple G-protein-coupled receptors. Pharmacol Res Perspect 32 14489 PMID: 23077035
An et al (2014) Neuritin can normalize neural deficits of Alzheimer's disease. Cell Death Dis 5 e1523 PMID: 25393479
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.