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Submit ReviewGue 1654
Discontinued Product
4742 has been discontinued.
View all Heterotrimeric G-protein GTPases products.
Description: Selective inhibitor of OXE-R Gβ/γ signaling
Chemical Name: N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide
Purity: ≥97% (HPLC)
Biological Activity for Gue 1654
Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator. Selectively inhibits Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Inhibits Gβγ-mediated opening of GIRK1/2 channels in HEK293 cells.
Technical Data for Gue 1654
| M. Wt | 447.6 |
| Formula | C23H17N3OS3 |
| Storage | Store at +4°C |
| Purity | ≥97% (HPLC) |
| CAS Number | 397290-30-1 |
| PubChem ID | 5066134 |
| InChI Key | UFOBDFMYJABXGK-UHFFFAOYSA-N |
| Smiles | O=C(C(C5=CC=CC=C5)C4=CC=CC=C4)NC(S3)=NC1=C3C(SC(SC)=N2)=C2C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Gue 1654
References for Gue 1654
References are publications that support the biological activity of the product.
Blättermann et al (2012) A biased ligand for OXE-R uncouples Gα and Gβγ signaling within a heterotrimer Nat.Chem.Biol. 8 631 PMID: 22634634
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Keywords: Gue 1654, Gue 1654 supplier, Gue1654, OXE-R, modulators, inhibitors, inhibits, selective, beta, gamma, β, γ, signalling, signaling, heterotrimeric, G-proteins, oxeiocosanoid, receptors, Heterotrimeric, G-protein, GTPases, Leukotriene, and, Related, Receptors, 4742, Tocris Bioscience
1 Citation for Gue 1654
Citations are publications that use Tocris products. Selected citations for Gue 1654 include:
Nogueras-Ortiz (2017) Retromer stops beta-arrestin 1 mediated signaling from internalized cannabinoid 2 receptors. Mol Biol Cell 28 3554 PMID: 28954865
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