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Submit ReviewGYY 4137 morpholine salt
Description: Slow-releasing H2S donor
Chemical Name: P-(4-Methoxyphenyl)-P-4-morpholinylphosphinodithioic acid morpholine salt
Biological Activity for GYY 4137 morpholine salt
GYY 4137 morpholine salt is a slow-releasing H2S donor. Exhibits vasodilator and antihypertensive activity. Activity causes slow dilation of blood vessels in vitro and in vivo; does not influence vascular smooth muscle cell viability in culture. Water-soluble.
Technical Data for GYY 4137 morpholine salt
| M. Wt | 376.47 |
| Formula | C11H16NO2PS2.C4H9NO |
| Storage | Store at -20°C |
| CAS Number | 106740-09-4 |
| PubChem ID | 46937261 |
| InChI Key | YZMHNNLDUWRZFW-UHFFFAOYSA-N |
| Smiles | S=P(N1CCOCC1)(C2=CC=C(OC)C=C2)S.N3CCOCC3 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for GYY 4137 morpholine salt
References for GYY 4137 morpholine salt
References are publications that support the biological activity of the product.
Li et al (2008) Characterization of a novel, water-soluble hydrogen sulfide-releasing molecule (GYY4137). Circulation 117 2351 PMID: 18443240
Whiteman et al (2010) The effect of hydrogen sulfide donors on lipopolysaccaride-induced formation of inflammatory mediators in macrophages. Antioxid.Redox.Signal. 12 1147 PMID: 19769459
Lee et al (2011) The slow-releasing hydrogen sulfide donor, GYY4137, exhibits novel anti-cancer effects in vitro and in vivo. PLoS One 6 e21077 PMID: 21701688
Liu et al (2013) Hydrogen sulfide donor, GYY4137, exhibits anti-atherosclerotic activity in high fat fed apolipoprotein E-/- mice. Br.J.Pharmacol. [Epub ahead of print] PMID: 23713790
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Keywords: GYY 4137 morpholine salt, GYY 4137 morpholine salt supplier, GYY4137, morpholine, h2s, hydrogen, sulfide, sulphide, donors, slow, releasing, release, vasodilator, antihypertensives, Miscellaneous, Compounds, 3658, Tocris Bioscience
1 Citation for GYY 4137 morpholine salt
Citations are publications that use Tocris products. Selected citations for GYY 4137 morpholine salt include:
Y S et al (2020) Hydrogen sulfide, oxygen, and calcium regulation in developing human airway smooth muscle. FASEB J 34 12991-13004 PMID: 32777143
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