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Submit ReviewHEAT hydrochloride
Description: Highly selective α1 antagonist
Alternative Names: BE 2254
Chemical Name: 2-{[β-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for HEAT hydrochloride
HEAT hydrochloride is a very selective α1-adrenoceptor antagonist, precursor of the 3-[125I]-derivative.
Technical Data for HEAT hydrochloride
| M. Wt | 331.84 |
| Formula | C19H21NO2.HCl |
| Storage | Desiccate at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 30007-39-7 |
| PubChem ID | 34771 |
| InChI Key | VCZXZECZIRGUCZ-UHFFFAOYSA-N |
| Smiles | Cl.OC1=CC=C(CCNCC2CCC3=CC=CC=C3C2=O)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for HEAT hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 33.18 | 100 |
Preparing Stock Solutions for HEAT hydrochloride
The following data is based on the product molecular weight 331.84. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.07 mL | 30.14 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.03 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for HEAT hydrochloride
References for HEAT hydrochloride
References are publications that support the biological activity of the product.
Baumgarten et al (1972) Mechanisms of pressor effect of 5,6-dihydroxytryptamine in pithed rats. Naunyn Schmiedebergs Arch.Pharmacol. 274 375 PMID: 4404780
Williams et al (1978) Interaction of 2-[β-(4-hydroxyphenyl)ethylaminomethyl]tetralone (BE 2254: 'HEAT') with catecholamine receptors in rat brain membranes. J.Pharm.Pharmacol. 30 390 PMID: 26778
If you know of a relevant reference for HEAT hydrochloride, please let us know.
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Keywords: HEAT hydrochloride, HEAT hydrochloride supplier, selective, α1-adrenoceptor, alpha1-adrenoceptor, a1-adrenoceptor, antagonists, a1-adrenergic, α1-adrenergic, alpha1-adrenergic, Receptors, BE2254, 2-{[b-(4-Hydroxyphenyl)ethyl]aminomethyl}-1-tetralone, hydrochloride, BE, 2254, Adrenergic, Alpha-1, 0535, Tocris Bioscience
3 Citations for HEAT hydrochloride
Citations are publications that use Tocris products. Selected citations for HEAT hydrochloride include:
Grisanti et al (2011) α1-adrenergic receptors positively regulate Toll-like receptor cytokine production from human monocytes and macrophages. J Pharmacol Exp Ther 338 648 PMID: 21571945
Cardin and Schmidt (2004) Noradrenergic inputs mediate state dependence of auditory responses in the avian song system. Circ Res 24 7745 PMID: 15342742
Jasmin et al (2002) The NK1 receptor mediates both the hyperalgesia and the resistance to mor. in mice lacking noradrenaline. Proc Natl Acad Sci U S A 99 1029 PMID: 11805341
Do you know of a great paper that uses HEAT hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Depression Poster
Major depressive disorder is characterized by depressed mood and a loss of interest and/or pleasure. Updated in 2015 this poster highlights presynaptic and postsynaptic targets for the potential treatment of major depressive disorder, as well as outlining the pharmacology of currently approved antidepressant drugs.