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Submit ReviewHistamine dihydrochloride
Description: Endogenous histamine receptor agonist
Chemical Name: 2-(4-Imidazolyl)ethylamine dihydrochloride
Biological Activity for Histamine dihydrochloride
Histamine dihydrochloride is an endogenous agonist at histamine receptors (H1-4). Released from mast cells and basophils and exhibits inflammatory, vasodilatory and bronchoconstrictory activity. Stimulates gastric acid secretion and acts as a neurotransmitter in vivo.
Compound Libraries for Histamine dihydrochloride
Histamine dihydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Histamine dihydrochloride
| M. Wt | 184.07 |
| Formula | C5H9N3.2HCl |
| Storage | Desiccate at RT |
| CAS Number | 56-92-8 |
| PubChem ID | 5818 |
| InChI Key | PPZMYIBUHIPZOS-UHFFFAOYSA-N |
| Smiles | NCCC1=CNC=N1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Histamine dihydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 18.41 | 100 | |
| DMSO | 18.41 | 100 |
Preparing Stock Solutions for Histamine dihydrochloride
The following data is based on the product molecular weight 184.07. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 5.43 mL | 27.16 mL | 54.33 mL |
| 5 mM | 1.09 mL | 5.43 mL | 10.87 mL |
| 10 mM | 0.54 mL | 2.72 mL | 5.43 mL |
| 50 mM | 0.11 mL | 0.54 mL | 1.09 mL |
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Product Datasheets for Histamine dihydrochloride
References for Histamine dihydrochloride
References are publications that support the biological activity of the product.
Hill et al (1997) International union of pharmacology. XIII. Classification of histamine receptors. Pharmacol.Rev. 49 253 PMID: 9311023
Thurmond et al (2008) The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines. Nat.Rev.Drug Discov. 7 41 PMID: 18172439
Maintz and Novak (2007) Histamine and histamine intolerance. Am.J.Clin.Nutr. 85 1185 PMID: 17490952
If you know of a relevant reference for Histamine dihydrochloride, please let us know.
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Keywords: Histamine dihydrochloride, Histamine dihydrochloride supplier, Endogenous, histamine, receptor, agonists, H4, Receptors, Histamine, H1, H2, H3, histaminergic, 3545, Tocris Bioscience
9 Citations for Histamine dihydrochloride
Citations are publications that use Tocris products. Selected citations for Histamine dihydrochloride include:
Chen et al (2017) Bone Marrow Myeloid Cells Regulate Myeloid-Biased Hematopoietic Stem Cells via a Histamine-Dependent Feedback Loop. Cell Stem Cell 21 747 PMID: 29198940
Femenia et al (2015) Hippocampal-Dependent Antidepressant Action of the H3 Receptor Antagonist Clobenpropit in a Rat Model of Depression. Int J Neuropsychopharmacol 18 PMID: 25762718
Gerhold et al (2015) Pronociceptive and Antinociceptive Effects of Bupren. in the Spinal Cord Dorsal Horn Cover a Dose Range of Four Orders of Magnitude. J Neurosci 35 9580 PMID: 26134641
Vincenzo et al (2021) 2-Pentadecyl-2-oxazoline ameliorates memory impairment and depression-like behaviour in neuropathic mice: possible role of adrenergic alpha2- and H3 histamine autoreceptors. Mol Brain 14 28 PMID: 33557888
Melchior and Frangos (2012) Gαq/11-mediated intracellular calcium responses to retrograde flow in endothelial cells. Acta Pharmacol Sin 303 C467 PMID: 22700794
David E et al (2022) A serotonergic axon-cilium synapse drives nuclear signaling to alter chromatin accessibility. Cell 185 3390-3407.e18 PMID: 36055200
JoAnn et al (2019) G protein-coupled receptors activate p38 MAPK via a non-canonical TAB1-TAB2- and TAB1-TAB3-dependent pathway in endothelial cells. J Biol Chem 294 5867-5878 PMID: 30760523
Hao et al (2019) A Genetically Encoded Fluorescent Sensor for Rapid and Specific In Vivo Detection of Norepinephrine. Neuron 102 745-761.e8 PMID: 30922875
Thomas C et al (2019) Neuromodulator Signaling Bidirectionally Controls Vesicle Numbers in Human Synapses. Cell 179 498-513.e22 PMID: 31585084
Do you know of a great paper that uses Histamine dihydrochloride from Tocris? Please let us know.
Reviews for Histamine dihydrochloride
Average Rating: 4 (Based on 1 Review.)
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Histamine releases Ca2+ from ER stores in EA.hy926 cells..
By
Niroj Shrestha on 12/04/2018
Assay Type: In Vitro
Species: Human
Cell Line/Tissue: EA.hy926
EA.hy926 cells were loaded with cytosolic Ca2+ sensitive dye, Fura-2AM in normal tyrode solution for 40 min and excited alternately at 340 and 380 nm and fluorescence was captured at 510 nm. ER Ca2+ store was depleted with 100 µM histamine in 0.1 mM EGTA-tyrode solution, resulting in transient cytosolic Ca2+ peak.
Literature in this Area
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Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.