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Submit ReviewIbotenic acid
Description: NMDA agonist; also non selective mGlu agonist
Chemical Name: α-Amino-(3-hydroxy-5-isoxazolyl)acetic acid
Purity: ≥98% (HPLC)
Biological Activity for Ibotenic acid
Ibotenic acid is a NMDA and metabotropic glutamate receptor agonist.
Technical Data for Ibotenic acid
| M. Wt | 158.11 |
| Formula | C5H6N2O4 |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 2552-55-8 |
| PubChem ID | 1233 |
| InChI Key | IRJCBFDCFXCWGO-UHFFFAOYSA-N |
| Smiles | NC(C(O)=O)C1=CC(O)=NO1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Ibotenic acid
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 1.58 | 10 | |
| 1.1eq. NaOH | 15.81 | 100 |
Preparing Stock Solutions for Ibotenic acid
The following data is based on the product molecular weight 158.11. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.32 mL | 31.62 mL | 63.25 mL |
| 5 mM | 1.26 mL | 6.32 mL | 12.65 mL |
| 10 mM | 0.63 mL | 3.16 mL | 6.32 mL |
| 50 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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Product Datasheets for Ibotenic acid
References for Ibotenic acid
References are publications that support the biological activity of the product.
Johnston et al (1968) Central actions of ibotenic acid and muscimol. Biochem.Pharmacol. 17 2488 PMID: 5752907
Nakanishi (1992) Molecular diversity of glutamate receptors and implications for brain functions. Science 258 597 PMID: 1329206
Pin and Duvoisin (1995) The metabotropic glutamate receptors: structure and functions. Neuropharmacology 34 1 PMID: 7623957
Watkins and Evans (1981) Excitatory amino acid transmitters. Annu.Rev.Pharmacol.Toxicol. 21 165 PMID: 6112965
If you know of a relevant reference for Ibotenic acid, please let us know.
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Keywords: Ibotenic acid, Ibotenic acid supplier, Non-Selective, NMDA, agonists, mGlur, Glutamate, Receptors, N-Methyl-D-Aspartate, iGluR, Ionotropic, Metabotropic, Non-selective, mGlu, 0285, Tocris Bioscience
4 Citations for Ibotenic acid
Citations are publications that use Tocris products. Selected citations for Ibotenic acid include:
Karlsson et al (2013) Exaggerated cue-induced reinstatement of cocaine seeking but not incubation of cocaine craving in a developmental rat model of schizophrenia. Psychopharmacology (Berl) 226 45 PMID: 23010798
Pitts and Takahashi (2011) The central amygdala nucleus via corticotropin-releasing factor is necessary for time-limited consolidation processing but not storage of contextual fear memory. Neuroreport 95 86 PMID: 21093597
Renouard et al (2015) The supramammillary nucleus and the claustrum activate the cortex during REM sleep. Neurobiol Learn Mem 1 e1400177 PMID: 26601158
Joseph et al (2018) Role of Prefrontal Cortex Anti- and Pro-inflammatory Cytokines in the Development of Abnormal Behaviors Induced by Disconnection of the Ventral Hippocampus in Neonate Rats. Front Behav Neurosci 12 244 PMID: 30459571
Do you know of a great paper that uses Ibotenic acid from Tocris? Please let us know.
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