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Submit ReviewIC 87201
Description: nNOS-PSD95 protein-protein interaction inhibitor; also antinociceptive and antidepressant
Chemical Name: 2-[(1H-Benzotriazol-6-ylamino)methyl]-4,6-dichlorophenol
Purity: ≥99% (HPLC)
Biological Activity for IC 87201
IC 87201 is an inhibits binding of the NMDA receptor postsynaptic density protein 95 kDa (PSD95) to nNOS (EC50 = 23.94 μM), while not affecting the PSD95-ErbB4 interaction. Inhibits glutamate-induced cell death in cultured cortical neurons. Exhibits antinociceptive effects in inflammatory pain models in vivo. Also exhibits antidepressant-like activitiy in animal models.
Technical Data for IC 87201
| M. Wt | 309.15 |
| Formula | C13H10Cl2N4O |
| Storage | Store at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 866927-10-8 |
| PubChem ID | 11771269 |
| InChI Key | QEHVTUCLCBXQIC-UHFFFAOYSA-N |
| Smiles | OC1=C(C=C(C=C1Cl)Cl)CNC2=CC=C3N=NNC3=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for IC 87201
References for IC 87201
References are publications that support the biological activity of the product.
Doucet et al (2013) Small-molecule inhibitors at the PSD-95/nNOS interface have antidepressant-like properties in mice. Neuropsychopharmacology. 38 1575 PMID: 23446451
Lee et al (2015) Small molecule inhibitors of PSD95-nNOS protein-protein interactions as novel analgesics. Neuropharmacology. 97 464 PMID: 26071110
Florio et al (2009) Disruption of nNOS-PSD95 protein-protein interaction inhibits acute thermal hyperalgesia and chronic mechanical allodynia in rodents. Br.J.Pharmacol. 158 494 PMID: 19732061
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Keywords: IC 87201, IC 87201 supplier, IC87201, postsynaptic, density, protein, 95, PSD95, nNOS, NMDA, protein-protein, interactions, inhibitors, inhibits, binding, antinociceptive, antidepressant, Receptors, 6226, Tocris Bioscience
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Currently there are no citations for IC 87201.
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