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Submit ReviewICI 162,846
Discontinued Product
0833 has been discontinued.
View all Histamine H<sub>2</sub> Receptors products.
Description: Potent H2 antagonist, active in vivo
Chemical Name: N-[1-(4-Carboxamidobutyl)-1H-pyrazol-3-yl)]-N'-(2,2,2-trifluoroethyl)guanidine
Biological Activity for ICI 162,846
ICI 162,846 is a potent histamine H2 receptor antagonist.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ICI 162,846
| M. Wt | 306.29 |
| Formula | C11H17F3N6O |
| Storage | Store at RT |
| CAS Number | 84545-30-2 |
| PubChem ID | 134778 |
| InChI Key | ALCSGJCIESECFD-UHFFFAOYSA-N |
| Smiles | NC(=O)CCCCN1C=CC(=N1)\N=C(/N)NCC(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ICI 162,846
Certificate of Analysis is currently unavailable on-line.
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References for ICI 162,846
References are publications that support the biological activity of the product.
Gompertz et al (1991) Acid blockade by omeprazole or ICI 162846 in a chronic duodenal ulcer model. Agents Actions 33 161 PMID: 1716826
Streett et al (1988) Morphological stomach findings in rats and mice treated with the H2 receptor antagonists, ICI 125,211 and ICI 162,846. Toxicol.Pathol. 16 299 PMID: 2903545
Wilson et al (1986) Inhibition of human gastric secretion by ICI 162,846 - a new histamine H2 receptor antagonist. Br.J.Clin.Pharmacol. 21 685 PMID: 2874823
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Keywords: ICI 162,846, ICI 162,846 supplier, Potent, H2, antagonists, active, vivo, Receptors, Histamine, histaminergic, ICI162846, AstraZeneca, 0833, Tocris Bioscience
Citations for ICI 162,846
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Currently there are no citations for ICI 162,846.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.