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Submit ReviewICI 185,282
Description: Potent thromboxane receptor antagonist
Chemical Name: 5-(Z)-7-(4-o-Hydroxyphenyl-2-trifluoromethyl-1,3 dioxan-cis-5-yl)heptenoic acid
Biological Activity for ICI 185,282
Potent thromboxane receptor antagonist.
Licensing Information
Sold with the permission of AstraZeneca UK Ltd.
Technical Data for ICI 185,282
| M. Wt | 374.36 |
| Formula | C18H21F3O5 |
| Storage | Desiccate at -20°C |
| CAS Number | 106393-80-0 |
| PubChem ID | 5311390 |
| InChI Key | ZWAVGFSZMACJHA-PMNBYGLBSA-N |
| Smiles | OC(=O)CCC\C=C/C[C@@H]1CO[C@@H](O[C@@H]1C1=C(O)C=CC=C1)C(F)(F)F |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for ICI 185,282
Certificate of Analysis is currently unavailable on-line.
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References for ICI 185,282
References are publications that support the biological activity of the product.
Birch et al (1988) Studies in the guinea-pig with ICI 185,282: a thromboxane A2 receptor antagonist. J.Pharm.Pharmacol. 40 706 PMID: 2907537
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Keywords: ICI 185,282, ICI 185,282 supplier, Potent, thromboxane, A2, TXA2, receptors, antagonists, TP, Prostanoid, prostaglandins, prostacyclins, eicosanoids, ICI185282, AstraZeneca, Receptors, 0836, Tocris Bioscience
1 Citation for ICI 185,282
Citations are publications that use Tocris products. Selected citations for ICI 185,282 include:
Kleinbongard et al (2011) Vasoconstrictor potential of coronary aspirate from patients undergoing stenting of saphenous vein aortocoronary bypass grafts and its pharmacological attenuation. Circ Res 108 344 PMID: 21183739
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