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Submit ReviewImetit dihydrobromide
Description: Standard H3 and H4 agonist (H3 > H4)
Chemical Name: 5-[2-(Imidazol-4-yl)ethyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Biological Activity for Imetit dihydrobromide
Imetit dihydrobromide is an an extremely potent, high affinity agonist at H3 and H4 receptors (Ki values are 0.3 and 2.7 nM respectively). Induces shape change in eosinophils with an EC50 of 25 nM. Centrally active following systemic administration.
Technical Data for Imetit dihydrobromide
| M. Wt | 332.06 |
| Formula | C6H10N4S.2HBr |
| Storage | Store at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 32385-58-3 |
| PubChem ID | 11957573 |
| InChI Key | DOBOYMKCRRLTRF-UHFFFAOYSA-N |
| Smiles | Br.Br.NC(=N)SCCC1=CNC=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Imetit dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 33.21 | 100 |
Preparing Stock Solutions for Imetit dihydrobromide
The following data is based on the product molecular weight 332.06. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.01 mL | 15.06 mL | 30.12 mL |
| 5 mM | 0.6 mL | 3.01 mL | 6.02 mL |
| 10 mM | 0.3 mL | 1.51 mL | 3.01 mL |
| 50 mM | 0.06 mL | 0.3 mL | 0.6 mL |
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Product Datasheets for Imetit dihydrobromide
References for Imetit dihydrobromide
References are publications that support the biological activity of the product.
Farzin and Attarzadeh (2000) Influence of different histamine receptor agonists and antagonists on apomorphine-induced licking behavior in rats. Eur.J.Pharmacol. 404 169 PMID: 10980276
Garbarg et al (1992) S-[2-(4-Imidazolyl)ethyl]isothiourea, a highly specific and potent histamine H3 receptor agonist. J.Pharmacol.Exp.Ther. 263 304 PMID: 1383495
Ling et al (2004) Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation. Br.J.Pharmacol. 142 161 PMID: 15131002
If you know of a relevant reference for Imetit dihydrobromide, please let us know.
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Keywords: Imetit dihydrobromide, Imetit dihydrobromide supplier, H3, H4, agonists, Receptors, Histamine, histaminergic, 0729, Tocris Bioscience
3 Citations for Imetit dihydrobromide
Citations are publications that use Tocris products. Selected citations for Imetit dihydrobromide include:
Hashikawa-Hobara et al (2012) Histamine 3 receptor activation reduces the expression of neuronal angiotensin II type 1 receptors in the heart. Evid Based Complement Alternat Med 340 185 PMID: 22011436
Yoshimoto et al (2006) Therapeutic potential of histamine H3 receptor agonist for the treatment of obesity and diabetes mellitus. Proc Natl Acad Sci U S A 103 13866 PMID: 16954192
Flamand et al (2004) Histamine-induced inhibition of leukotriene biosynthesis in human neutrophils: involvement of the H2 receptor and cAMP. Br J Pharmacol 141 552 PMID: 14744809
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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