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Submit ReviewImipramine hydrochloride
Description: Potent inhibitor of 5-HT and noradrenalin transporters; promotes immunostimulatory tumor microenvironment
Chemical Name: 5-(3-Dimethylaminopropyl)-10,11-dihydro-5H-dibenz[b,f]azepine hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for Imipramine hydrochloride
Imipramine hydrochloride is a potent tricyclic antidepressant; inhibits 5-HT and noradrenalin transporters (Ki values = 1.3-20 nM and 20-142 nM respectively). Increases autophagy, both alone and in combination with VEGF inhibitors or Temozolomide (Cat. No. 2706), to reduce the progression of glioma and slow the proliferation of other tumors. Reprograms tumor-associated macrophages from immunosuppressive to immunostimulatory via histamine receptor inhibition.
Compound Libraries for Imipramine hydrochloride
Imipramine hydrochloride is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for Imipramine hydrochloride
| M. Wt | 316.87 |
| Formula | C19H24N2.HCl |
| Storage | Store at -20°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 113-52-0 |
| PubChem ID | 8228 |
| InChI Key | XZZXIYZZBJDEEP-UHFFFAOYSA-N |
| Smiles | CN(C)CCCN(C1=C(CC2)C=CC=C1)C3=C2C=CC=C3.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Imipramine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 15.84 | 50 | |
| water | 15.84 | 50 |
Preparing Stock Solutions for Imipramine hydrochloride
The following data is based on the product molecular weight 316.87. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.5 mM | 6.31 mL | 31.56 mL | 63.12 mL |
| 2.5 mM | 1.26 mL | 6.31 mL | 12.62 mL |
| 5 mM | 0.63 mL | 3.16 mL | 6.31 mL |
| 25 mM | 0.13 mL | 0.63 mL | 1.26 mL |
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Product Datasheets for Imipramine hydrochloride
References for Imipramine hydrochloride
References are publications that support the biological activity of the product.
Wang et al (2021) Imipramine impedes glioma progression by inhibiting YAP as a Hippo pathway independent manner and synergizes with temozolomide. J.Cell.Mol.Med. 25 9350 PMID: 34469035
Chryplewicz et al (2022) Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity. Cancer Cell 40 1111 PMID: 36113478
If you know of a relevant reference for Imipramine hydrochloride, please let us know.
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Keywords: Imipramine hydrochloride, Imipramine hydrochloride supplier, Imipramine, HCl, potent, inhibitors, inhibits, tricyclic, antidepressant, depression, autophagy, gliomas, tumors, macrophages, histamine, 5HT, noradrenalin, neurotransmitter, transporter, 5-HT, Transporters, Adrenergic, 7841, Tocris Bioscience
Citations for Imipramine hydrochloride
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.