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Description: Inhibitor of calcineurin-substrate association
Chemical Name: 9,10-Dihydro-9,10[1',2']-benzenoanthracene-1,4-dione
Purity: ≥95% (HPLC)
Biological Activity for INCA-6
INCA-6 is an inhibitor of interaction between calcineurin and its substrate nuclear factor of activated T cells (NFAT); blocks at the substrate recognition site but not at the catalytic site (Kd = 0.8 mM). Inhibits NFAT dephosphorylation and nuclear import. Also prevents induction of cytokine mRNAs that are downstream targets of NFAT.
Technical Data for INCA-6
| M. Wt | 284.31 |
| Formula | C20H12O2 |
| Storage | Store at -20°C |
| Purity | ≥95% (HPLC) |
| CAS Number | 3519-82-2 |
| PubChem ID | 230748 |
| InChI Key | GCHPUOHXXCNSQL-UHFFFAOYSA-N |
| Smiles | O=C1C=CC(=O)C2=C1C1C3=C(C=CC=C3)C2C2=C1C=CC=C2 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INCA-6
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 5.69 | 20 |
Preparing Stock Solutions for INCA-6
The following data is based on the product molecular weight 284.31. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.2 mM | 17.59 mL | 87.93 mL | 175.86 mL |
| 1 mM | 3.52 mL | 17.59 mL | 35.17 mL |
| 2 mM | 1.76 mL | 8.79 mL | 17.59 mL |
| 10 mM | 0.35 mL | 1.76 mL | 3.52 mL |
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Product Datasheets for INCA-6
References for INCA-6
References are publications that support the biological activity of the product.
Roehrl et al (2004) Selective inhibition of calcineurin-NFAT signaling by blocking protein-protein interaction with small organic molecules. Proc.Natl.Acad.Sci.USA 101 7554
If you know of a relevant reference for INCA-6, please let us know.
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Keywords: INCA-6, INCA-6 supplier, inhibitors, inhibits, calcineurin, Protein, Ser/Thr, Phosphatases, NFAT, 2162, Tocris Bioscience
3 Citations for INCA-6
Citations are publications that use Tocris products. Selected citations for INCA-6 include:
Savage et al (2015) RNA-Seq reveals a role for NFAT-signaling in human retinal microvascular endothelial cells treated with TNFα. PLoS One 10 e0116941 PMID: 25617622
Bretz et al (2015) NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis. Exp Eye Res 5 14963 PMID: 26527057
Faralli et al (2015) NFATc1 activity regulates the expression of myocilin induced by dexameth. Nat Chem Biol 130 42614 PMID: 25450062
Do you know of a great paper that uses INCA-6 from Tocris? Please let us know.
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