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Submit ReviewINCB 024360-analog
Description: Potent indoleamine 2,3-dioxygenase (IDO) inhibitor
Chemical Name: 4-Amino-N'-(3-chloro-4-fluorophenyl)-N-hydroxy-1,2,5-oxadiazole-3-carboximidamide
Purity: ≥99% (HPLC)
Biological Activity for INCB 024360-analog
INCB 024360-analog is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50 values are 19 and 67 nM in enzymatic activity and HeLa cell assays, respectively). Decreases kynurenine levels in plasma and reduces tumor growth in vivo. Cell membrane permeable.
Compound Libraries for INCB 024360-analog
INCB 024360-analog is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for INCB 024360-analog
| M. Wt | 271.64 |
| Formula | C9H7ClFN5O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 914471-09-3 |
| PubChem ID | 11978742 |
| InChI Key | MUVQOOPKPBEAJZ-VQHVLOKHSA-N |
| Smiles | O/N=C(NC1=CC(Cl)=C(F)C=C1)/C2=NON=C2N |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for INCB 024360-analog
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 27.16 | 100 | |
| ethanol | 27.16 | 100 |
Preparing Stock Solutions for INCB 024360-analog
The following data is based on the product molecular weight 271.64. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.68 mL | 18.41 mL | 36.81 mL |
| 5 mM | 0.74 mL | 3.68 mL | 7.36 mL |
| 10 mM | 0.37 mL | 1.84 mL | 3.68 mL |
| 50 mM | 0.07 mL | 0.37 mL | 0.74 mL |
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Product Datasheets for INCB 024360-analog
References for INCB 024360-analog
References are publications that support the biological activity of the product.
Weinmann (2016) Cancer immunotherapy: selected targets and small-molecule modulators. Chem.Med.Chem. 11 450 PMID: 26836578
Yue et al (2009) Discovery of potent competitive inhibitors of indoleamine 2,3-dioxygenase with in vivo pharmacodynamic activity and efficacy in a mouse melanoma model. J.Med.Chem. 52 7364 PMID: 19507862
Dounay et al (2015) Challenges and opportunities in the discovery of new therapeutics targeting the kynurenine pathway. J.Med.Chem. 58 8762 PMID: 26207924
If you know of a relevant reference for INCB 024360-analog, please let us know.
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Keywords: INCB 024360-analog, INCB 024360-analog supplier, 1, Indoleamine, 2,3-dioxygenase, IDO, inhibitors, inhibits, cancer, immunology, 2,3, dioxygenase, Immune, Checkpoints, 6007, Tocris Bioscience
Citations for INCB 024360-analog
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