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Submit ReviewIodophenpropit dihydrobromide
Description: Potent, selective H3 antagonist
Chemical Name: N-[2-(4-Iodophenyl)ethyl]-S-[3-(4(5)-imidazolyl)propyl]isothiourea dihydrobromide
Purity: ≥98% (HPLC)
Biological Activity for Iodophenpropit dihydrobromide
Iodophenpropit dihydrobromide is a selective H3 antagonist with high affinity (KD = 0.3 nM).
Licensing Information
Sold with the permission of SCI, Amsterdam
Technical Data for Iodophenpropit dihydrobromide
| M. Wt | 576.13 |
| Formula | C15H19IN4S.2HBr |
| Storage | Desiccate at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 145196-87-8 |
| PubChem ID | 24978528 |
| InChI Key | BOSOGNBLIWPCMS-UHFFFAOYSA-N |
| Smiles | Br.Br.IC1=CC=C(CCNC(=N)SCCCC2=CNC=N2)C=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Iodophenpropit dihydrobromide
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 14.4 | 25 |
Preparing Stock Solutions for Iodophenpropit dihydrobromide
The following data is based on the product molecular weight 576.13. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.25 mM | 6.94 mL | 34.71 mL | 69.43 mL |
| 1.25 mM | 1.39 mL | 6.94 mL | 13.89 mL |
| 2.5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
| 12.5 mM | 0.14 mL | 0.69 mL | 1.39 mL |
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Product Datasheets for Iodophenpropit dihydrobromide
References for Iodophenpropit dihydrobromide
References are publications that support the biological activity of the product.
Jansen et al (1992) The first radiolabelled histamine H3 receptor antagonist, [125I]iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur.J.Pharmacol. 217 203 PMID: 1330590
Jansen et al (1994) Characterisation of the binding of the first selective radiolabelled histamine H3 receptor antagonist, [125I]-iodophenpropit, to rat brain. Br.J.Pharmacol. 113 355 PMID: 7834183
Menge et al (1992) Synthesis of S-[3-(4(5)-imidazolyl)propyl]-N-[2-(4-[125I]-iodophenylethyl]isothiourea sulfate [125I]-iodophenpropit), a new probe for histamine H3 receptor binding sites. J.Labelled Comp.Radiopharm. XXXI 10 781
Shahid et al (2009) Histamine, histamine receptors, and their role in immunomodulation: An updated systematic review. Open Immunol.J. 2 9
If you know of a relevant reference for Iodophenpropit dihydrobromide, please let us know.
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Keywords: Iodophenpropit dihydrobromide, Iodophenpropit dihydrobromide supplier, Potent, selective, H3, antagonists, Receptors, Histamine, histaminergic, 0779, Tocris Bioscience
2 Citations for Iodophenpropit dihydrobromide
Citations are publications that use Tocris products. Selected citations for Iodophenpropit dihydrobromide include:
Spaethling et al (2014) Serotonergic neuron regulation informed by in vivo single-cell transcriptomics. Toxins (Basel) 28 771 PMID: 24192459
Otvos et al (2015) Development of Plate Reader and On-Line Microfluidic Screening to Identify Ligands of the 5-Hydroxytryptamine Binding Protein in Venoms. BMC Neurosci 7 2336 PMID: 26114334
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
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