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Submit ReviewIsamoltane hemifumarate
Description: 5-HT1B antagonist
Chemical Name: 1-[(1-Methylethyl)amino]-3-[2-(1H-pyrrol-1-yl)]-propan-2-ol hemifumarate
Purity: ≥99% (HPLC)
Biological Activity for Isamoltane hemifumarate
Isamoltane hemifumarate is a 5-HT1B antagonist, approximately 30-fold selective over 5-HT1A. Also possesses affinity for β-adrenergic receptors.
Technical Data for Isamoltane hemifumarate
| M. Wt | 332.4 |
| Formula | C16H22N2O2.½C4H4O4 |
| Storage | Desiccate at +4°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 874882-92-5 |
| PubChem ID | 45073435 |
| InChI Key | MCHSBYUSDSJLAQ-WXXKFALUSA-N |
| Smiles | [H]OC(=O)\C=C\C(=O)O[H].CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1.CC(C)NCC(O)COC1=CC=CC=C1N1C=CC=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Isamoltane hemifumarate
References for Isamoltane hemifumarate
References are publications that support the biological activity of the product.
Waldmeier et al (1988) Interactions of isamoltane (CGP 361A), an anxiolytic phenoxypropanolamine derivative, with 5-HT1 receptor subtypes in the rat brain. Naunyn Schmiedebergs Arch.Pharmacol. 337 609 PMID: 2905765
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Keywords: Isamoltane hemifumarate, Isamoltane hemifumarate supplier, 5-HT1B, antagonist, Serotonin, Receptors, 0992, Tocris Bioscience
Citations for Isamoltane hemifumarate
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Currently there are no citations for Isamoltane hemifumarate.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
5-HT Receptors Scientific Review
Written by Nicholas M. Barnes and John F. Neumaier, this review summarizes the various serotonin receptor subtypes and their importance in mediating the role of serotonin in numerous physiological and pharmacological processes. Compounds available from Tocris are listed.
Parkinson's Disease Poster
Parkinson's disease (PD) causes chronic disability and is the second most common neurodegenerative condition. This poster outlines the neurobiology of the disease, as well as highlighting current therapeutic treatments for symptomatic PD, and emerging therapeutic strategies to delay PD onset and progression.