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Submit Reviewiso-PPADS tetrasodium salt
Description: Non-selective P2X antagonist
Chemical Name: Pyridoxalphosphate-6-azophenyl-2',5'-disulfonic acid tetrasodium salt
Biological Activity for iso-PPADS tetrasodium salt
iso-PPADS tetrasodium salt is a P2X-purinoceptor antagonist (pKi = 6.5) with similar activity to PPADS.
2'4'-isomer also available.
Technical Data for iso-PPADS tetrasodium salt
| M. Wt | 599.3 |
| Formula | C14H10N3Na4O12PS2 |
| Storage | Desiccate at -20°C |
| CAS Number | 207572-67-6 |
| PubChem ID | 5132514 |
| InChI Key | LOTSPVPQHAUHCE-UHFFFAOYSA-N |
| Smiles | [Na+].[Na+].CC1=C(O)C(C=O)=C(CCP([O-])([O-])=O)C(\N=N\C2=C(C=CC(=C2)S(O)(=O)=O)S(O)(=O)=O)=N1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for iso-PPADS tetrasodium salt
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 59.93 | 100 |
Preparing Stock Solutions for iso-PPADS tetrasodium salt
The following data is based on the product molecular weight 599.3. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 1.67 mL | 8.34 mL | 16.69 mL |
| 5 mM | 0.33 mL | 1.67 mL | 3.34 mL |
| 10 mM | 0.17 mL | 0.83 mL | 1.67 mL |
| 50 mM | 0.03 mL | 0.17 mL | 0.33 mL |
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Product Datasheets for iso-PPADS tetrasodium salt
References for iso-PPADS tetrasodium salt
References are publications that support the biological activity of the product.
Connolly (1995) Differentiation by pyridoxal 5-phosphate, PPADS and isoPPADS between responses mediated by UTP and those evoked by α,β-methylene-ATP on rat sympathetic ganglia. Br.J.Pharmacol. 114 727 PMID: 7735699
Khakh et al (1994) Estimates of antagonist affinities at P2X purinoceptors in rat vas deferens. Eur.J.Pharmacol. 263 301 PMID: 7843268
Trezise et al (1994) The use of antagonists to characterize the receptors mediating depolarization of the rat isolated vagus nerve by α,β-methylene adenosine 5'-triphosphate. Br.J.Pharmacol. 112 282 PMID: 8032652
If you know of a relevant reference for iso-PPADS tetrasodium salt, please let us know.
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Keywords: iso-PPADS tetrasodium salt, iso-PPADS tetrasodium salt supplier, P2X, antagonists, Receptors, Purinergic, purinoceptors, 0683, Tocris Bioscience
5 Citations for iso-PPADS tetrasodium salt
Citations are publications that use Tocris products. Selected citations for iso-PPADS tetrasodium salt include:
Schneider et al (2015) Extracellular nucleotides as novel, underappreciated pro-metastatic factors that stimulate purinergic signaling in human lung cancer cells. Am J Physiol Renal Physiol 14 201 PMID: 26597723
Accorsi-Mendonça et al (2013) Glial cells modulate the synaptic transmission of NTS neurons sending projections to ventral medulla of Wistar rats. Physiol Rep 1 e00080 PMID: 24303152
Uderhardt et al (2019) Resident Macrophages Cloak Tissue Microlesions to Prevent Neutrophil-Driven Inflammatory Damage. Cell 177 541 PMID: 30955887
Palygin et al (2018) Characterization of purinergic receptor expression in ARPKD cystic epithelia. Purinergic Signal 14 485 PMID: 30417216
Barría et al (2018) Trypanosoma cruzi Infection Induces Pannexin-1 Channel Opening in Cardiac Myocytes. Am J Trop Med Hyg 98 105 PMID: 29141748
Do you know of a great paper that uses iso-PPADS tetrasodium salt from Tocris? Please let us know.
Reviews for iso-PPADS tetrasodium salt
Average Rating: 5 (Based on 1 Review.)
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Good inhibitor.
By
Anonymous on 06/06/2020
Assay Type: In Vivo
Species: Mouse
Cell Line/Tissue: phagocyte
H20 dilution 100 μM
Literature in this Area
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P2X and P2Y Receptors Scientific Review
Written by Kenneth Jacobson, this review provides an overview of the different subtypes and structures of the P2 receptor families, as well as the pharmacological probes used to study them; compounds available from Tocris are listed.