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Submit ReviewIsoguvacine hydrochloride
Description: Selective GABAA agonist
Chemical Name: 1,2,3,6-Tetrahydro-4-pyridinecarboxylic acid hydrochloride
Purity: ≥99% (HPLC)
Biological Activity for Isoguvacine hydrochloride
Isoguvacine hydrochloride is a specific GABAA receptor agonist. Suppresses low magnesium induced seizure like events in organotypic hippocampal brain slices.
Technical Data for Isoguvacine hydrochloride
| M. Wt | 163.6 |
| Formula | C6H9NO2.HCl |
| Storage | Store at RT |
| Purity | ≥99% (HPLC) |
| CAS Number | 68547-97-7 |
| PubChem ID | 155107 |
| InChI Key | SUWREQRNTXCCBL-UHFFFAOYSA-N |
| Smiles | Cl.OC(=O)C=1CCNCC1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for Isoguvacine hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| water | 100 |
Preparing Stock Solutions for Isoguvacine hydrochloride
The following data is based on the product molecular weight 163.6. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 6.11 mL | 30.56 mL | 61.12 mL |
| 5 mM | 1.22 mL | 6.11 mL | 12.22 mL |
| 10 mM | 0.61 mL | 3.06 mL | 6.11 mL |
| 50 mM | 0.12 mL | 0.61 mL | 1.22 mL |
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Product Datasheets for Isoguvacine hydrochloride
References for Isoguvacine hydrochloride
References are publications that support the biological activity of the product.
Krogsgaard-Larsen et al (1978) Structure-activity studies on the inhibition of GABA binding to rat brain membranes by muscimol and related compounds. J.Neurochem. 30 1377 PMID: 670980
Krogsgaard-Larsen et al (1979) Dihydromuscimol, thiomuscimol and related heterocyclic compounds as GABA analogues. J.Neurochem. 32 1717 PMID: 448364
Wahab et al (2009) Effects of gamma-aminobutyric acid (GABA) agonists and a GABA uptake inhibitor on pharmacoresistant seizure like events in organotypic hippocampal slice cultures. Epilepsy Res. 86 113 PMID: 19535226
If you know of a relevant reference for Isoguvacine hydrochloride, please let us know.
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Keywords: Isoguvacine hydrochloride, Isoguvacine hydrochloride supplier, Selective, GABAA, agonists, Receptors, 0235, Tocris Bioscience
5 Citations for Isoguvacine hydrochloride
Citations are publications that use Tocris products. Selected citations for Isoguvacine hydrochloride include:
Sipilä et al (2009) Compensatory enhancement of intrinsic spiking upon NKCC1 disruption in neonatal hippocampus. J Neurosci 29 6982 PMID: 19474325
Long et al (2009) Nerve Terminal GABAA Receptors Activate Ca2+/Calmodulin-dependent Signaling to Inhibit Voltage-gated Ca2+ Influx and Glutamate Release. Br J Pharmacol 284 8726 PMID: 19141616
Lobb et al (2010) A dynamic role for GABA receptors on the firing pattern of midbrain DArgic neurons. J Neurophysiol 104 403 PMID: 20445035
Edwards et al (2011) Amino acid derivatives are substrates or non-transported inhibitors of the amino acid transporter PAT2 (slc36a2). Biochim Biophys Acta 1808 260 PMID: 20691150
Wood et al (2000) The human GABA(B1b) and GABA(B2) heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen. J Neurosci 131 1050 PMID: 11082110
Do you know of a great paper that uses Isoguvacine hydrochloride from Tocris? Please let us know.
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
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Written by Ian Martin, Norman Bowery and Susan Dunn, this review provides a history of the GABA receptor, as well as discussing the structure and function of the various subtypes and the clinical potential of receptor modulators; compounds available from Tocris are listed.
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