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Submit ReviewIsotretinoin
Description: Endogenous agonist for retinoic acid receptors; inducer of neuronal differentiation
Alternative Names: 13-cis-retinoic acid,Accutane
Chemical Name: 13-cis-Retinoic acid
Purity: ≥99% (HPLC)
Biological Activity for Isotretinoin
Endogenous agonist for retinoic acid receptors. Promotes neurite outgrowth, cell differentiation and inhibits proliferation in a neuroblastoma cell line. Also increases protein expression levels of MYCN and retinoic acid receptor-β. Anti-inflammatory.
Technical Data for Isotretinoin
| M. Wt | 300.44 |
| Formula | C20H28O2 |
| Storage | Store at -20°C |
| Purity | ≥99% (HPLC) |
| CAS Number | 4759-48-2 |
| PubChem ID | 5282379 |
| InChI Key | SHGAZHPCJJPHSC-XFYACQKRSA-N |
| Smiles | C/C(/C=C/C=C(C)/C=C/C1=C(C)CCCC(C)1C)=C/C(O)=O |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for Isotretinoin
References for Isotretinoin
References are publications that support the biological activity of the product.
Diamandis et al (2007) Chemical genetics reveals a complex functional ground state of neural stem cells. Nat.Chem.Biol. 3 268 PMID: 17417631
Blaner et al (2001) Cellular metabolism and actions of 13-cis-retinoic acid. J.Am.Acad.Dermatol. 45 S129 PMID: 11606944
Sonawane et al (2014) Metabolic characteristics of 13-cis-retinoic acid (isotretinoin) and anti-tumour activity of the 13-cis-retinoic acid metabolite 4-oxo-13-cis-retinoic acid in neuroblastoma. Br.J.Pharmacol. 171 5330 PMID: 25039756
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Keywords: Isotretinoin, Isotretinoin supplier, Endogenous, agonists, retinoic, acid, receptors, neuronal, differentiation, anti-inflammatory, RAR, Retinoic, Acid, Receptors, RXR, Retinoid, X, 13-cis-retinoic, Accutane, Receptor, Neural, Stem, Cells, Retinal, 5513, Tocris Bioscience
⚠ WARNING: This product can expose you to chemicals including Isotretinoin, which is known to the State of California to cause reproductive toxicity with developmental effects. For more information, go to www.P65Warnings.ca.gov
1 Citation for Isotretinoin
Citations are publications that use Tocris products. Selected citations for Isotretinoin include:
Cicero et al (2016) A High Throughput Phenotypic Screening reveals compounds that counteract premature osteogenic differentiation of HGPS iPS-derived mesenchymal stem cells. Sci Rep 6 34798 PMID: 27739443
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Retinoid Receptors Scientific Review
Written by Alexander Moise, this review summarizes the nature of retinoid receptors, their isotype and isoform variants and modulation of retinoid signaling. Compounds available from Tocris are listed.