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Submit ReviewJMS 17-2 hydrochloride
Description: CX3CR1 antagonist
Chemical Name: 5-[3-[4-(4-Chlorophenyl)-1-piperidinyl]propyl]pyrrolo[1,2-a]quinoxalin-4(5H)-one hydrochloride
Purity: ≥98% (HPLC)
Biological Activity for JMS 17-2 hydrochloride
JMS 17-2 hydrochloride is a chemokine CX3CR1 (fractalkine receptor) antagonist. Inhibits fractalkine-induced ERK phosphorylation and decreases migration of breast cancer cells in vitro. Also inhibits circulating tumor cells from seeding into bone and reduces overall tumor burden in a breast cancer metastasis model.
Licensing Information
Sold under license from Drexel University.
Compound Libraries for JMS 17-2 hydrochloride
JMS 17-2 hydrochloride is also offered as part of the Tocriscreen Antiviral Library. Find out more about compound libraries available from Tocris.
Technical Data for JMS 17-2 hydrochloride
| M. Wt | 456.41 |
| Formula | C25H26ClN3O.HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 2341841-07-2 |
| Smiles | ClC1=CC=C(C2CCN(CC2)CCCN3C(C4=CC=CN4C5=CC=CC=C35)=O)C=C1.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JMS 17-2 hydrochloride
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| DMSO | 45.64 | 100 | |
| ethanol | 22.82 | 50 |
Preparing Stock Solutions for JMS 17-2 hydrochloride
The following data is based on the product molecular weight 456.41. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 2.19 mL | 10.96 mL | 21.91 mL |
| 5 mM | 0.44 mL | 2.19 mL | 4.38 mL |
| 10 mM | 0.22 mL | 1.1 mL | 2.19 mL |
| 50 mM | 0.04 mL | 0.22 mL | 0.44 mL |
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Product Datasheets for JMS 17-2 hydrochloride
References for JMS 17-2 hydrochloride
References are publications that support the biological activity of the product.
Shen et al (2016) Novel small-molecule CX3CR1 antagonist impairs metastatic seeding and colonization of breast cancer cells. Mol. Cancer Res. 14 518 PMID: 27001765
If you know of a relevant reference for JMS 17-2 hydrochloride, please let us know.
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Keywords: JMS 17-2 hydrochloride, JMS 17-2 hydrochloride supplier, JMS17-2, hydrochloride, HCl, 1380392-05-1, fractalkine, receptor, antagonists, antagonism, cx3cr1, chemokines, Other, Chemokine, Receptors, 6378, Tocris Bioscience
Citations for JMS 17-2 hydrochloride
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