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Submit ReviewJNJ 10181457 dihydrochloride
Discontinued Product
4019 has been discontinued.
View all Histamine H<sub>3</sub> Receptors products.
Description: H3 antagonist
Chemical Name: 4-[3-[4-[Piperidinyl]but-1-ynyl]benzyl]morpholine dihydrochloride
Purity: ≥98% (HPLC)
Biological Activity for JNJ 10181457 dihydrochloride
Histamine H3 receptor antagonist (pKi values are 8.15 and 8.93 for rat and human H3 receptors respectively). Increases extracellular norepinephrine and acetylcholine levels in rat frontal cortex but does not stimulate dopamine release. Brain penetrant.
Licensing Information
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Technical Data for JNJ 10181457 dihydrochloride
| M. Wt | 385.37 |
| Formula | C20H28N2O.2HCl |
| Storage | Desiccate at RT |
| Purity | ≥98% (HPLC) |
| CAS Number | 544707-20-2 |
| PubChem ID | 10237424 |
| InChI Key | PAQHERKZFLOHCA-UHFFFAOYSA-N |
| Smiles | C1(CN2CCOCC2)=CC=CC(C#CCCN3CCCCC3)=C1.Cl.Cl |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Product Datasheets for JNJ 10181457 dihydrochloride
References for JNJ 10181457 dihydrochloride
References are publications that support the biological activity of the product.
Bonaventure et al (2007) Histamine H3 receptor antagonists: from target identification to drug leads. Biochem.Pharmacol. 73 1084 PMID: 17129577
Esbenshade et al (2008) The histamine H3 receptor: an attractive target for the treatment of cognitive disorders. Br.J.Pharmacol. 154 1166 PMID: 18469850
Boggs et al (2009) JNJ-10181457, a selective non-imidazole histamine H3 receptor antagonist, normalizes acetylcholine neurotransmission and has efficacy in translational rat models of cognition. Neuropharmacology 56 1131 PMID: 19345233
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Keywords: JNJ 10181457 dihydrochloride, JNJ 10181457 dihydrochloride supplier, JNJ10181457, dihydrochloride, histamine, h3, receptors, antagonists, brain, penetrant, Histamine, H3, Receptors, 4019, Tocris Bioscience
1 Citation for JNJ 10181457 dihydrochloride
Citations are publications that use Tocris products. Selected citations for JNJ 10181457 dihydrochloride include:
Iida (2017) JNJ10181457, a histamine H3 receptor inverse agonist, regulates in vivo microglial functions and improves depression-like behaviours in mice. Biochem Biophys Res Commun 488 534 PMID: 28526411
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Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.
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