Submit a Review & Earn an Amazon Gift Card
You can now submit reviews for your favorite Tocris products. Your review will help other researchers decide on the best products for their research. Why not submit a review today?!
Submit ReviewJNJ 7777120
Description: Selective H4 antagonist
Chemical Name: 1-[(5-Chloro-1H-indol-2-yl)carbonyl]-4-methylpiperazine
Purity: ≥98% (HPLC)
Biological Activity for JNJ 7777120
JNJ 7777120 is a histamine H4 receptor antagonist; displays high affinity (Ki = 4.5 nM) and is >1000-fold selective for H4 over other histamine receptors.
Licensing Information
Sold with the permission of Ortho-McNeil-Janssen Pharmaceuticals, Inc.
Compound Libraries for JNJ 7777120
JNJ 7777120 is also offered as part of the Tocriscreen 2.0 Max. Find out more about compound libraries available from Tocris.
Technical Data for JNJ 7777120
| M. Wt | 277.75 |
| Formula | C14H16ClN3O |
| Storage | Store at +4°C |
| Purity | ≥98% (HPLC) |
| CAS Number | 459168-41-3 |
| PubChem ID | 4908365 |
| InChI Key | HUQJRYMLJBBEDO-UHFFFAOYSA-N |
| Smiles | ClC1=CC=C(NC(C(N3CCN(C)CC3)=O)=C2)C2=C1 |
The technical data provided above is for guidance only. For batch specific data refer to the Certificate of Analysis.
Tocris products are intended for laboratory research use only, unless stated otherwise.
Solubility Data for JNJ 7777120
| Solvent | Max Conc. mg/mL | Max Conc. mM | |
|---|---|---|---|
| Solubility | |||
| 1eq. HCl | 27.77 | 100 | |
| DMSO | 13.89 | 50 |
Preparing Stock Solutions for JNJ 7777120
The following data is based on the product molecular weight 277.75. Batch specific molecular weights may vary from batch to batch due to the degree of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 1 mM | 3.6 mL | 18 mL | 36 mL |
| 5 mM | 0.72 mL | 3.6 mL | 7.2 mL |
| 10 mM | 0.36 mL | 1.8 mL | 3.6 mL |
| 50 mM | 0.07 mL | 0.36 mL | 0.72 mL |
Molarity Calculator
Molarity Calculator
Calculate the mass, volume, or concentration required for a solution.
Reconstitution Calculator
Reconstitution Calculator
Dilution Calculator
Dilution Calculator
Calculate the dilution required to prepare a stock solution.
Product Datasheets for JNJ 7777120
References for JNJ 7777120
References are publications that support the biological activity of the product.
Jablanowski et al (2003) The first potent and selective non-imidazole human histamine H4 receptor antagonists. J.Med.Chem. 46 3957 PMID: 12954048
Thurmond et al (2004) A potent and selective histamine H4 receptor antagonist with anti-inflammatory properties. J.Pharmacol.Exp.Ther. 309 404 PMID: 14722321
Strakhova et al (2009) In vitro and in vivo characterization of A-940894: a potent histamine H4 receptor antagonist with anti-inflammatory properties. Br.J.Pharmacol. 157 44 PMID: 19413570
If you know of a relevant reference for JNJ 7777120, please let us know.
View Related Products by Target
View Related Products by Product Action
Keywords: JNJ 7777120, JNJ 7777120 supplier, JNJ7777120, histamine, 4, histaminergic, H4, receptors, antagonists, selective, Histamine, Receptors, 4021, Tocris Bioscience
2 Citations for JNJ 7777120
Citations are publications that use Tocris products. Selected citations for JNJ 7777120 include:
Fang et al (2019) Activation of Mast-Cell-Expressed Mas-Related G-Protein-Coupled Receptors Drives Non-histaminergic Itch. Immunity 50 1163-1171.e5 PMID: 31027996
David et al (2020) Inflammation-induced IgE promotes epithelial hyperplasia and tumour growth. Elife 9 PMID: 31931959
Do you know of a great paper that uses JNJ 7777120 from Tocris? Please let us know.
Reviews for JNJ 7777120
There are currently no reviews for this product. Be the first to review JNJ 7777120 and earn rewards!
Have you used JNJ 7777120?
Submit a review and receive an Amazon gift card.
$50/€35/£30/$50CAN/¥300 Yuan/¥5000 Yen for first to review with an image
$25/€18/£15/$25CAN/¥75 Yuan/¥2500 Yen for a review with an image
$10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen for a review without an image
Literature in this Area
Tocris offers the following scientific literature in this area to showcase our products. We invite you to request* your copy today!
*Please note that Tocris will only send literature to established scientific business / institute addresses.
Histamine Receptors Scientific Review
Written by Iwan de Esch and Rob Leurs, this review provides a synopsis of the different histamine receptor subtypes and the ligands that act upon them; compounds available from Tocris are listed.